Results 41 to 50 of about 74,738 (303)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Impact of PWM strategies on RMS current of the DC-link Voltage Capacitor of a dual-three phase drive [PDF]

open access: yes, 2014
The major drawback of usual dual three-phase AC machines, when supplied by a Voltage Source Inverter (VSI), is the occurrence of extra harmonic currents which circulate in the stator windings causing additional losses and constraints on the power ...
ROUHANA, Najib   +5 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

HPFs filtering solutions for reduced the harmonic current generated by SMPS and ac drive systems

open access: yesEnergy Reports, 2020
This paper proposes a reduced 2nd, 3rd, 5th and 7th harmonic current of all power supply units and ac drives which effects of heating neutral cables and transformer.
K. Kularbphettong, C. Boonseng
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Electric System Design of SDA1 AC Drive Diesel Locomotive Exporting to Australia

open access: yes机车电传动, 2012
Components and performance of traction drive system, auxiliary drive system and control system of SDA1 locomotive were described systematically, and new technology and equipment application of the locomotive was introduced.
HAN Xiao   +4 more
doaj  

Systematic Implementation and Performance Evaluation of Multiphase Power Converter in Medium Voltage Drive System

open access: yesIET Energy Systems Integration
Investigation of power converters for use in industrial drive applications finds that these converters are used low reliable components. To overcome this issue, in this paper, advanced power converters (multi‐pulse AC–DC and multilevel DC–AC converter ...
Bhim Singh, Rohit Kumar
doaj   +1 more source

Reactive power flow optimization in AC drive systems

open access: yes2025 IEEE 64th Conference on Decision and Control (CDC)
This paper explores a limit avoidance approach in the case of input (modulation) and output (current) constraints with the aim of enhancing system availability of AC drives. Drawing on the observation that, in a certain range of reactive power, there exists a trade-off between current and modulation magnitude, we exploit this freedom and define a ...
Sanjay Chandrasekaran   +4 more
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Research on Semi-physical Simulation for the Main Drive System of High PowerAC-DC-AC Rolling Mill

open access: yesKongzhi Yu Xinxi Jishu, 2014
It analyzed a semi-physical simulation system for the main drive system of high-power AC-DC-AC rolling mill based on dSPACE. Virtual scene were constructed for the simulation system, debugging and test running environment were made through real-time ...
TAN Juan, ZHANG Yu, CHEN Liusong
doaj  

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