Results 51 to 60 of about 9,012,324 (313)

The Impact of a Camp Orientation Program on First-Year Academic Engagement and Persistence

Journal of College Orientation, Transition, and Retention, 2013
More and more, institutions of higher education are being held accountable for student success measures such as persistence and completion rates. If research indicates that higher levels of student engagement lead to better academic outcomes, it is then ...
Michael R. Haynes, T. Wayne Atchley
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

‘Academic Leadership’ and the Conditions of Academic Work

, 2016
For those concerned with teaching and scholarly work in higher education now, talk of ‘academic leadership’ is everywhere. In the UK, at any rate, it seems so: scanning academic jobs pages, looking at Research Councils’ funding schemes, examining government policy documents on higher education, consulting university promotions and appraisals procedures,
Richard Allen, Suman Gupta
openaire   +2 more sources

ACADEMIC VIRTUE AND ACADEMIC LEADERSHIP

Leader. Elite. Society, 2021
the work contains substantiation of a mutual link between academic virtue and academic leadership. The reasons for academic virtue violation by applicants for higher education have been analyzed, and the main areas of working with them have been determined.
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

MEMBANGUN ACADEMIC SELF-CONCEPT MAHASANTRI PESANTREN NAWESEA

Education Human and Development Journal, 2018
Pengkajian ini dimaksudkan untuk membahas konsep diri mahasantri dalam hal akademik di Pesantren Nawesea, Yogyakarta. Sebagai lembaga pendidikan non-formal yang dikelola lembaga swasta, pesantren ini menawarkan program pada pengembangan bahasa asing ...
Shulhan Alfinnas
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Analyzing Business Education Tutorials: Significant Problems and Workable Solutions [PDF]

E3S Web of Conferences
The accounting department of the Papua New Guinea University of Technology has observed a concerning pattern in the academic performance of its students, particularly in preparation for their final exams.
Sigl Jennifer, Mohamed Aezeden
doaj   +1 more source