Results 61 to 70 of about 9,279,615 (317)

Analyzing Business Education Tutorials: Significant Problems and Workable Solutions [PDF]

open access: yesE3S Web of Conferences
The accounting department of the Papua New Guinea University of Technology has observed a concerning pattern in the academic performance of its students, particularly in preparation for their final exams.
Sigl Jennifer, Mohamed Aezeden
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Beyond the on-line library - the Learning Environment

open access: yesInformation Research: An International Electronic Journal, 1997
This paper describes a collaborative project which has defined requirements and a model for holistic networked learner support. Based on these requirements, a working prototype for a Learning Environment has been developed.
Bob Banks
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Practising the paradigm shift: real world experience of on-line support

open access: yesInformation Research: An International Electronic Journal, 1997
Development of an externally funded groundbreaking course for the Internet environment at the University of Southern Queensland has provided valuable experience. The course was designed by a multidisciplinary team, including librarians.
Madeleine McPherson
doaj  

Dictatorship in a single export crop economy [PDF]

open access: yes
Is it a matter of pure altruism or short-sightedness when a dictator spends an increasing amount of his revenues for the population, while cutting on own consumption? In order to be able to consume, the dictator first has to stay in power.
Bart Capéau   +2 more
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Non-welfare economics and the well-being of phantom agents: an appeal to caution [PDF]

open access: yes
Besley (1988) is one of the few exceptional articles containing non-welfarist optimal tax devices. Feehan(1990) reports an error in his first-best rules. The present note criticizes the fundamentals of Besley's second-best rules. These rules optimize the
Bart Capéau, Erwin Ooghe
core  

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