Results 71 to 80 of about 9,279,615 (317)

Academic Makerspaces [PDF]

open access: yes, 2017
Makerspaces allow people to create and learn in a supportive environment and are growing in popularity. Hear how university libraries across the UK are creating different types of makerspace to support the hands-on learning of their wider academic communities.
openaire   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

On the reconciliation of efficiency and inequality aversion with heterogeneous populations: characterization results [PDF]

open access: yes
We characterize a family of r-extended generalized Lorenz dominance quasi-orderings and a family of r-Gini welfare orderings, on the basis of two allegedly "incompatible" axioms for heterogeneous welfare comparisons (Ebert, 1997, Ebert and Moyes, 2003 ...
Bart Capéau, Erwin Ooghe
core  

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

Exploration de l’activité de publication et de recherche de vidéos sur une plateforme audiovisuelle académique en ligne

open access: yesActivités, 2018
Publishing and searching for videos online are two common human activities that remain under-investigated today. We investigated these two related activities through interviews with users of an online academic audiovisual database.
Emmanuelle Papinot   +2 more
doaj   +1 more source

Prices, unit values and local measurement units in rural surveys: an econometric approach with an application to poverty measurement in Ethiopia [PDF]

open access: yes
For many research problems in developing countries, some information on prices faced by households is required for the analysis, for example if subsistence consumption is a substantial part of consumption.
Bart Capéau, Stefan Dercon
core  

Rethinking Research Partnerships: Discussion Guide and Toolkit [PDF]

open access: yes, 2017
In recent years, there has been a drive towards research collaboration between academics and international non-governmental organisations (INGOs). These new partnerships offer exciting opportunities to improve learning and practice in international ...
Cornish, Hilary   +2 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Technical Efficiency Evaluation: Naturally Dual! [PDF]

open access: yes
We provide a dual perspective on technical efficiency evaluation, in two respects. First, we build on the price assumptions implicitly associated with the notion of technical efficiency in a general equilibrium framework to characterize a set of ...
Laurens Cherchye, Tom Van Puyenbroeck
core  

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