Results 41 to 50 of about 7,314,511 (242)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Textual Metadiscourse Resources in Research Articles [PDF]

Journal of English Language Teaching and Learning, 2009
This study was motivated by three factors, which also contribute to its significance for today’s academic writing. First, research articles are the significant means of communication between the writers all over the world.
Farahman farrokhi, Somayeh Ashrafi
doaj  

Disciplinary differences in the experience of online education among teachers and students in Chinese universities during COVID-19

Frontiers in Psychology, 2022
Online education has advantages during COVID-19, but it also has problems related to hardware support and user experience. Focusing on teaching quality by discipline is an effective way to improve teaching quality in universities.
Shuo Yu, Ying Liu, Bingqing Yang, Zhiwei Chen   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Negotiating writing: a case study of the transition of English second-language Social Science graduates to postgraduate professional disciplines [PDF]

, 2012
Includes abstract.Includes bibliographical references.This longitudinal, qualitative case study provides thick description of six English second-language (ESL) students' transition from Social Science disciplines to postgraduate study in the professional
Bangeni, Abongwe
core   +1 more source

Gender and academic discipline influences on EFL learners' perceptions of video-based instruction

Australian Journal of Applied Linguistics
This study explores the perceptions of educational videos in English as a Foreign Language (EFL) learning among students from different gender groups and academic disciplines, specifically Social Sciences, Humanities, STEM, and Health Sciences. Using an
Olusiji Lasekan, Margot Teresa Godoy Pena   +1 more
doaj   +1 more source

Neurophysiological advantages of biorelevant methodology of teaching academic disciplines

Открытое образование (Москва), 2017
The analysis of technology of teaching a biorelevant lesson showed when using a traditional methodology of teaching (the sinistrocerebral one), there is a contradiction between social and biological aspects of the cerebrum functional system.
Natalia A. Davidovskaya
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Några internationella perspektiv på en forskningspolitik i förändring

Kulturella Perspektiv, 2008
We asked give former guest scholars to send us a short report on the current situation for cultural research in their home countries. This article is an attempt to summarise these reports and it touches on questions of funding, evaluating and conducting
Martin Fredriksson
doaj   +1 more source