Results 61 to 70 of about 838,813 (358)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Spatial CT perfusion data helpful in automatically locating vessel occlusions for acute ischemic stroke patients

Frontiers in Neurology, 2023
IntroductionLocating a vessel occlusion is important for clinical decision support in stroke healthcare. The advent of endovascular thrombectomy beyond proximal large vessel occlusions spurs alternative approaches to locate vessel occlusions.
Daan Peerlings, Hugo W. A. M. de Jong, Edwin Bennink, Edwin Bennink, Jan W. Dankbaar, Birgitta K. Velthuis, Bart J. Emmer, Charles B. L. M. Majoie, Henk A. Marquering, Henk A. Marquering   +9 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Enrichment of type 1 innate lymphoid cells in the course of human atherosclerotic plaque development suggests contribution to atherogenesis

Frontiers in Immunology
IntroductionInnate lymphoid cells (ILCs) have been implicated in multiple pathologic conditions, including atherogenesis, as documented in experimental mice studies, however, their role in atherosclerosis in humans remains unexplored.MethodsHere, we ...
Kartika R. Pertiwi, Kartika R. Pertiwi, Marcel B. M. Teunissen, Gabrielle Krebbers, Martine C.M. Willems, Martine C.M. Willems, Laurens Huisman, Laurens Huisman, Cindy Poelen, Allard C. van der Wal, Onno J. de Boer   +10 more
doaj   +1 more source

Fatigue in children and adolescents perinatally infected with human immunodeficiency virus: an observational study

BMC Pediatrics, 2021
Background Fatigue is common among adults living with human immunodeficiency virus (HIV) as well as children with a chronic disease (CCD). Fatigue can have disastrous effects on health status, including health related quality of life (HRQOL).
A. M. ter Haar, M. M. Nap-van der Vlist, M. Van den Hof, S. L. Nijhof, R. R. L. van Litsenburg, K. J. Oostrom, D. Pajkrt   +6 more
doaj   +1 more source

Interprofessional Health Care Education at Academic Medical Centers: Using a SWOT Analysis to Develop and Implement Programming

MedEdPORTAL, 2018
Introduction Health care is increasingly being provided by interprofessional teams. Academic medical centers (AMCs) need to offer educational experiences for trainees to work on these teams.
D. Topor, C. Dickey, Laura Stonestreet, Judith Wendt, Adam B. Woolley, A. Budson   +5 more
semanticscholar   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Load distribution after unilateral condylar fracture with shortening of the ramus: a finite element model study

Head & Face Medicine, 2023
Objectives After a fracture of the condyle, the fractured ramus is often shortened, which causes premature dental contact on the fractured side and a contralateral open bite.
Loreine M. L. Helmer, Cornelis Klop, Frank Lobbezoo, Jan de Lange, Jan Harm Koolstra, Leander Dubois   +5 more
doaj   +1 more source

Current evidence on the adoption of indicator condition guided testing for HIV in western countries: A systematic review and meta-analysis

EClinicalMedicine, 2021
Background: Indicator condition (IC) guided testing for HIV is an effective way to identify undiagnosed people living with HIV, but studies suggest its implementation is lacking.
S.J. Bogers, S.H. Hulstein, M.F. Schim van der Loeff, G.J. de Bree, P. Reiss, J.E.A.M van Bergen, S.E. Geerlings   +6 more
doaj   +1 more source

Medical service plans in academic medical centers

Academic Medicine, 1978
Medical service plans are of major importance to academic medical centers and are becoming increasingly so each year as evidenced by growing dependence of medical schools on resulting funds. How these funds are generated and used varies among schools.
openaire   +3 more sources