Results 111 to 120 of about 462,748 (309)

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Life satisfaction and self-efficacy in patients affected by a first stroke living in Kuwait: A two-phase study [PDF]

, 2013
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2012 Informa Healthcare USA, Inc.Life satisfaction and self-efficacy are important aspects of stroke rehabilitation.
Omu, O, Onutobor Omu, Frances Reynolds, Reynolds, F   +3 more
core   +1 more source

Highly Active Cu14 Cluster Precisely Activates Autophagy Inhibitor to Amplify Cuproptosis Immunotherapy

Advanced Science, EarlyView.
An atomically precise Cu14 cluster‐mediated bond scission reaction pioneers the amplification of the antitumor immune response via synergetic cuproptosis‐associated immunogenic cell death induction and in situ autophagy blockade. ABSTRACT Transition metal‐mediated cleavage mechanisms have emerged as an effective means to mitigate the off‐target ...
Qiu‐Xu Zang, Wei‐Tong Chen, Yu‐Ying Shen, Zhao‐Yang Wang, Kai Li, Xueli Zhao, Yanjuan Sang, Xiaoyuan Chen, Shuang‐Quan Zang   +8 more
wiley   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Students academic self-perception [PDF]

Participation rates in higher education differ persistently between some groups in society. Using two British datasets we investigate whether this gap is rooted in students' mis-perception of their own and other's ability, thereby increasing the expected
Sherria Hoskins, Martin Snell, Arnaud Chevalier, Steve Gibbons, Andy Thorpe   +4 more
core   +2 more sources

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

Native American Studies Program APR Self Study

, 2014
Native American Studies Program Academic Program Review Self Study ReportNative American Studies Program Academic Program Review Self Study ReportNative American Studies ...
Native American Studies Program Academic Program Review Self Study Report, APR Self Study Report
core  

Influence of self-efficacy and goal orientation on academic achievements among Chinese junior middle school students [PDF]

The aim of this study was to explore factors influencing academic performance. It surveyed 400 junior high school respondents through questionnaire forms and analyzed the results using methods like Spearman rank correlation and Mann-Whitney U.
Mustakim, Siti Salina, Zou, Yuxue
core   +1 more source

Examining the Effects of Academic Stress, Self‐Efficacy, Cognitive–Behavioral Outcomes, Psychological Distress, and Prosocial Behavior: A Moderated‐Mediation Model

Brain and Behavior
Background Academic stress significantly affects students’ well‐being and academic performance. This study addresses this gap by exploring how academic self‐efficacy mediates the relationship between academic stress and both educational and psychological
Wang Chongjin, Iftikhar Ahmed Charan, Shazia Soomro   +2 more
doaj   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source