Results 51 to 60 of about 59,954 (359)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Institute of musicology, Serbian Academy of Sciences and Arts (1948-2010) [PDF]
Muzikologija, 2010 The article gives an overview of the early days of the Institute, then proceeds to explain the development of the research projects, the further education of research members of the Institute and finally the results of the Institute?s work in various fields: research, publishing, building of archival collections, popularization of research.
openaire +3 more sources
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Emerging Areas of Science: Recommendations for Nursing Science Education from the Council for the Advancement of Nursing Science Idea Festival [PDF]
, 2015 The Council for the Advancement of Nursing Science aims to “facilitate and recognize life-long nursing science career development” as an important part of its mission.
Alt-White, Anna C. +10 more
core +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
CONSIDERATIONS REGARDIND THE SCIENTIFIC GROUNDS FOR SETTING UP SECURITY STRATEGIES [PDF]
Annals: Series on Military Sciences, 2016 The main objective of the paper is to present a point of view on scientific approaches towards the security strategy so as to create opportunities to intensify the exchange of scientific ideas between scientists.
Mihai ILIESCU, Eugen SITEANU
doaj
Scaling Up: Reform Lessons for Urban Comprehensive High Schools [PDF]
, 2005 Policy interest in the challenge of improving urban high schools has grown recently, as high-profile business leaders and politicians have called the preparedness of graduates for college work into question.
core
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Real-Time Systems: Reflections on higher education in the Czech Republic, Hungary, Poland and Slovenia [PDF]
, 2003 Real-time systems (An ICT definition)\ud In real-time multiprocessing there is the extra requirement that the system complete its response to any input within a certain critical time.
File, Jon, Goedegebuure, Leo
core +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source