Results 81 to 90 of about 59,954 (359)

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

The U.S. Commitment to Global Health: Recommendations for the New Administration [PDF]

, 2008
Outlines the need for making a commitment to improving global health an integral part of U.S. foreign policy. Suggestions include creating a White House Interagency Committee on Global Health and directing more funds to chronic disease ...

core  

The metric tide: report of the independent review of the role of metrics in research assessment and management [PDF]

, 2015
This report presents the findings and recommendations of the Independent Review of the Role of Metrics in Research Assessment and Management. The review was chaired by Professor James Wilsdon, supported by an independent and multidisciplinary group of ...
Allen, Liz, Belfiore, Eleonora, Campbell, Philip, Curry, Stephen, Hill, Jude, Hill, Steven, Johnson, Ben, Jones, Richard, Kain, Roger, Kerridge, Simon, Thelwall, Mike, Tinkler, Jane, Viney, Ian, Wilsdon, James, Wouters, Paul   +14 more
core   +3 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Special issue dedicated to 70th anniversary of foundation of Institute of Hydrology, Slovak Academy of Sciences, Bratislava, Slovakia [PDF]

, 2023
Yvetta Velísková
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Definindo prioridades de gestão de ciência e tecnologia em saúde

Revista de Saúde Pública
INTRODUÇÃO: A necessidade de gestão da produção científica e tecnológica em saúde está bem estabelecida no Brasil desde a realização da I Conferência Nacional de Ciência e Tecnologia (C&T) em Saúde, em 1994.
Júlio Cesar Rodrigues Pereira, Sueli Gonzales Saes, Maria Mercedes Loureiro Escuder   +2 more
doaj  

Knowledge Integration and Diffusion: Measures and Mapping of Diversity and Coherence

, 2014
I present a framework based on the concepts of diversity and coherence for the analysis of knowledge integration and diffusion. Visualisations that help understand insights gained are also introduced. The key novelty offered by this framework compared to
A Skupin, A Stirling, AL Porter, AL Porter, AL Porter, C Chen, C Ricotta, CR Rao, EJ Hackett, F Havemann, F Moya-Anegón, G Dosi, H Etzkowitz, I Rafols, I Rafols, I Rafols, I Rafols, K Börner, KW Boyack, KW Boyack, KW Boyack, L Leydesdorff, L Leydesdorff, L Leydesdorff, L Leydesdorff, L Leydesdorff, L Leydesdorff, L Nesta, L Nesta, L Waltman, LK Hessels, M Gibbons, M Rosvall, National Academies, P Ahlgren, P Jensen, P Lowe, P Nightingale, R Barré, R Klavans, R Klavans, RA Boschma, S Carley, S Soós, S Soós, TJ Pinch, X Polanco, Y Kajikawa, Y Takeda, YX Liu, YX Liu   +50 more
core   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Divergence or Convergence in Research and Development and Innovation Between ‘East’ and ‘West’? [PDF]

, 1999
Book description: Research suggests that innovation and technological change are crucial for the economic recovery of the former centrally planned countries in Central and Eastern Europe.
Radosevic, S
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