Acanthamoeba induces cell-cycle arrest in host cells [PDF]
, 2004 Acanthamoeba can cause fatal granulomatous amoebic encephalitis (GAE) and eye keratitis. However, the pathogenesis and pathophysiology of these emerging diseases remain unclear.
Alizadeh +41 more
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Acanthamoeba genotype T4 from the UK and Iran and isolation of the T2 genotype from clinical isolates [PDF]
, 2005 The majority of the keratitis-causing Acanthamoeba isolates are genotype T4. In an attempt to determine whether predominance of T4 isolates in Acanthamoeba keratitis is due to greater virulence or greater prevalence of this genotype, Acanthamoeba ...
Alsam +21 more
core +1 more source
Acanthamoeba castellanii induces host cell death via a phosphatidylinositol 3-kinase-dependent mechanism [PDF]
, 2005 Granulomatous amoebic encephalitis due to Acanthamoeba castellanii is a serious human infection with fatal consequences, but it is not clear how the circulating amoebae interact with the blood-brain barrier and transmigrate into the central nervous ...
Alsam, S. +5 more
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Post-mortem culture of Balamuthia mandrillaris from the brain and cerebrospinal fluid of a case of granulomatous amoebic meningoencephalitis, using human brain microvascular endothelial cells [PDF]
, 2004 The first isolation in the UK of Balamuthia mandrillaris amoebae from a fatal case of granulomatous amoebic meningoencephalitis is reported. Using primary cultures of human brain microvascular endothelial cells (HBMECs), amoebae were isolated from the ...
Alsam +32 more
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Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds [PDF]
, 2007 Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp.
Henriquez, Fiona L. +4 more
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The intron-containing gene for yeast profilin (PFY) encodes a vital function [PDF]
, 1988 The gene coding for profilin (PFY), an actin-binding protein, occurs as a single copy in the haploid genome of Saccharomyces cerevisiae and is required for spore germination and cell viability.
Bandlow, Wolfhard +3 more
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Induced encystment improves resistance to preservation and storage of Acanthamoeba castellanii [PDF]
, 2008 Several conditions that allow the preservation, storage and rapid, efficient recovery of viable Acanthamoeba castellanii organisms were investigated. The viability of trophozoites (as determined by time to confluence) significantly declined over a period
Campbell, S. J. +3 more
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Microorganisms and Common Ophthalmic Diseases [PDF]
, 2017 The human eye is in constant contact to environmental conditions that increase its likelihood in being exposed to a multitude of pathogens. Studies have revealed that the normal microbial flora found around the ocular area contribute to the well-being of
Su CW, Tighe S
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The cyclic AMP phosphodiesterase RegA critically regulates encystation in social and pathogenic amoebas [PDF]
, 2014 Amoebas survive environmental stress by differentiating into encapsulated cysts. As cysts, pathogenic amoebas resist antibiotics, which particularly counteracts treatment of vision-destroying Acanthamoeba keratitis. Limited genetic tractability of amoeba
Birgersson, Elin +5 more
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The pathogenesis of Acanthamoeba infections: current status and future implications [PDF]
, 2004 Acanthamoeba are opportunistic protozoan parasites that can cause painful, visionthreatening keratitis. However the pathogenesis and pathophysiology of Acanthamoeba keratitis remain incompletely understood. Most cases of Acanthamoeba keratitis develop
Khan, Naveed Ahmed
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