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Microorganisms and Common Ophthalmic Diseases [PDF]
The human eye is in constant contact to environmental conditions that increase its likelihood in being exposed to a multitude of pathogens. Studies have revealed that the normal microbial flora found around the ocular area contribute to the well-being of
Su CW, Tighe S
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Central nervous system infection with free-living amoebae is rare. We present a fatal case of Acanthamoeba encephalitis in a 63-year-old female from India where acanthamoebae were demonstrated and cultured from CSF. In spite of treatment with amphotericin B, fluconazole and rifampicin the patient did not survive.
Kaushal, V+5 more
openaire +2 more sources
Assessing Acanthamoeba cytotoxicity: comparison of common cell viability assays
BackgroundIn vitro models for studying interactions between Acanthamoeba and host cells are crucial for understanding the pathomechanism of Acanthamoeba and assessing differences between strains and cell types.
Alvie Loufouma Mbouaka+5 more
doaj +1 more source
Although the prevalence of Acanthamoeba keratitis (AK) is rare, its incidence in contact lens wearers has increased. Acanthamoeba infections can lead to the loss of vision if the diagnosis and treatment are delayed. In this study, we investigated the diagnostic potential of two antibodies raised against the adenylyl cyclase-associated protein (ACAP ...
Min-Jeong Kim+7 more
openaire +3 more sources
Contact Lens-Associated Acanthamoeba Keratitis in Iran [PDF]
Acanthamoeba keratitis is a vision-threatening infection caused by pathogenic species of the genus Acanthamoeba. In this study, 13 Acanthamoeba keratitis cases were diagnosed among 52 keratitis patients.
AH Maghsood+4 more
doaj +1 more source
Acanthamoeba encephalitis in immunocompetent hosts: A report of two cases
Acanthamoeba are ubiquitous free-living amoeba. Acanthamoeba infections cause necrotizing vasculitis, resulting in vessel thrombosis and cerebral infarction. Acanthamoeba CNS infections, though uncommon, are associated with high mortality.
Sohini Das+6 more
doaj +1 more source
Validation of reference genes for the normalization of RT-qPCR gene expression in Acanthamoeba spp.
Acanthamoebae are potentially pathogenic organisms, with a highly unique, yet still insufficiently investigated metabolism. Many open questions can be addressed by gene expression studies, however, for Acanthamoeba reliable standards have not yet been ...
M. Köhsler+3 more
semanticscholar +1 more source
Evolutionary Dynamics of Giant Viruses and their Virophages [PDF]
Giant viruses contain large genomes, encode many proteins atypical for viruses, replicate in large viral factories, and tend to infect protists. The giant virus replication factories can in turn be infected by so called virophages, which are smaller ...
Anderson+39 more
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An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment
Free-living amoebae of the genus Acanthamoeba are causal agents of a severe sight-threatening infection of the cornea known as Acanthamoeba keratitis. Moreover, the number of reported cases worldwide is increasing year after year, mostly in contact lens ...
J. Lorenzo-Morales+2 more
semanticscholar +1 more source
Acanthamoeba induces cell-cycle arrest in host cells [PDF]
Acanthamoeba can cause fatal granulomatous amoebic encephalitis (GAE) and eye keratitis. However, the pathogenesis and pathophysiology of these emerging diseases remain unclear.
Alizadeh+41 more
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