Results 81 to 90 of about 5,263 (211)

The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against Acanthamoeba castellanii. [PDF]

, 2020
Current treatments for Acanthamoeba keratitis rely on a combination of chlorhexidine gluconate, propamidine isethionate, and polyhexamethylene biguanide.
Podust, Larissa M, Shing, Brian, McKerrow, James H, Debnath, Anjan, Singh, Seema   +4 more
core   +1 more source

Novel insights into the potential role of ion transport in sensory perception in Acanthamoeba

Parasites & Vectors, 2019
Background Acanthamoeba is well known to produce a blinding keratitis and serious brain infection known as encephalitis. Effective treatment is problematic, and can continue up to a year, and even then, recurrence can ensue.
Ruqaiyyah Siddiqui, Stephen K. Roberts, Timothy Yu Yee Ong, Mohammad Ridwane Mungroo, Areeba Anwar, Naveed Ahmed Khan   +5 more
doaj   +1 more source

Eukaryote‐Wide Distribution of a Family of Longin Domain‐Containing GAP Complexes for Small GTPases

Traffic, Volume 26, Issue 7-9, July/September 2025.
The three longin domain‐containing GAP complexes ‐ CSW, folliculin, and GATOR1 ‐ have a sporadic but pan‐eukaryotic distribution and were likely already present in LECA in some form. Their catalytic longin domains contain highly conserved sequence motifs, some of which are shared with structurally similar proteins of Asgardarchaeota.
Anna M. G. Novák Vanclová, Catherine L. Jackson, Joel B. Dacks   +2 more
wiley   +1 more source

Rare Infectious Diseases: Detection and Clinical Implications

iLABMED, Volume 3, Issue 2, Page 148-157, June 2025.
Rare infectious diseases are infections that are uncommon, have a low incidence, and are caused by newly emerging pathogens, cross‐species or ectopic infections, or host immunodeficiencies. The detection and diagnosis of rare infections is one of the main reasons for misdiagnosis and missed diagnosis.
Xin Qian, Yuxin Zhang, Yilin Ye, Qiange Lin, Junyou Lin, Xinrong Lu, Li Chen, Guiqin Sun   +7 more
wiley   +1 more source

Paramoeba atlantica as a Natural Intracellular Niche for Vibrios in Marine Ecosystems

Environmental Microbiology, Volume 27, Issue 6, June 2025.
Various vibrios can colonise a large vacuole called VCV (Vibrio‐containing‐vacuole) within Paramoeba atlantica. The VCVs acidify and the vibrios multiply and remain alive inside the VCVs for hours. The vibrio found associated with Paramoeba atlantica can be pathogenic to oysters, suggesting that Paramoebidae are a potential reservoir for pathogens ...
Laura Onillon, Anaïs Dufau, Vincent Delafont, Hajar Amraoui, Etienne Robino, Angélique Perret, Océane Romatif, Juliette Pouzadoux, Thierry Soldati, Marie‐Agnès Travers, Guillaume M. Charrière   +10 more
wiley   +1 more source

Complete Mitochondrial Genomes of Ancyromonads Provide Clues for the Gene Content and Genome Structures of Ancestral Mitochondria

Journal of Eukaryotic Microbiology, Volume 72, Issue 3, May/June 2025.
ABSTRACT Mitochondria of eukaryotic cells are direct descendants of an endosymbiotic bacterium related to Alphaproteobacteria. These organelles retain their own genomes, which are highly reduced and divergent when compared to those of their bacterial relatives.
Ryo Harada, Takashi Shiratori, Akinori Yabuki, Yuji Inagaki, Andrew J. Roger, Ryoma Kamikawa   +5 more
wiley   +1 more source

Targeting pathogenic Acanthamoeba castellanii using DNA minor groove binding agents [PDF]

DNA minor groove binders exhibit a high degree of sequence specificity and have a variety of biological actions including antiviral, anticancer, antibacterial, and anti-protozoal properties.
Alawfi, Bader S., Alawfi, B. S, Ravi, Anil, Sajeev, Sreedevi, Al-Jubeh, Hadeel M., Daalah, M, Sajeev, S, Siddiqui, Ruqaiyyah; id_orcid, Khan, Naveed A., Siddiqui, R, Khan, N., Alniss, H. Y, Alniss, Hasan Y., Daalah, Meshal, AlJubeh, H. M, Ravi, A   +15 more
core   +1 more source

Dynamic and Reversible Tuning of Hydrogel Viscoelasticity by Transient Polymer Interactions for Controlling Cell Adhesion

Advanced Materials, Volume 37, Issue 12, March 26, 2025.
Biological systems are very responsive to changes in stiffness, influencing important processes, and diseases in humans. Here, a novel method to dynamically and reversibly control hydrogel stiffness through interactions with poly (ethylene glycol) (PEG) is presented. By exposing hydrogels to PEG solutions at different concentrations and sizes, hydrogel
Shane Scott, Maria Villiou, Federico Colombo, Angeles De la Cruz‐García, Leon Tydecks, Lotta Toelke, Katharina Siemsen, Christine Selhuber‐Unkel   +7 more
wiley   +1 more source

The pathogenesis of Acanthamoeba infections: current status and future implications

, 2004
Acanthamoeba are opportunistic protozoan parasites that can cause painful, visionthreatening keratitis. However the pathogenesis and pathophysiology of Acanthamoeba keratitis remain incompletely understood. Most cases of Acanthamoeba keratitis develop
Khan, Naveed Ahmed
core  

The role of Src kinase in the biology and pathogenesis of Acanthamoeba castellanii

Parasites & Vectors, 2012
Background Acanthamoeba species are the causative agents of fatal granulomatous encephalitis in humans. Haematogenous spread is thought to be a primary step, followed by blood–brain barrier penetration, in the transmission of Acanthmaoeba into the ...
Siddiqui Ruqaiyyah, Iqbal Junaid, Maugueret Marie-josée, Khan Naveed   +3 more
doaj   +1 more source