Results 71 to 80 of about 3,715 (174)

Metabolic Profile Associated With Encystation in Acanthamoeba

Journal of Eukaryotic Microbiology, Volume 72, Issue 5, September/October 2025.
ABSTRACT The genus Acanthamoeba includes widespread protozoa that can cause severe infections in humans. Their ability to form resistant cysts within infected tissues complicates treatment, making it essential to understand the encystation process for developing effective therapeutic strategies.
Cecília Cirelli, Isabela Aurora Rodrigues, Jéssica Gardone Vitório, Filipe Fideles Duarte‐Andrade, Gisele André Baptista Canuto, Leiliane Coelho André, Juliano Simões de Toledo, Ana Paula Fernandes, Adriana Oliveira Costa   +8 more
wiley   +1 more source

Seasonal Host Shifts for Legionella Within an Industrial Water‐Cooling System

Environmental Microbiology Reports, Volume 17, Issue 4, August 2025.
Taxonomic profiling for Legionella (the causative agent of Legionnaires' disease) and protist hosts within a water cooling tower showed seasonal peaks for Legionella that were associated with taxonomic shifts in the protist community. Legionella frequency was tracked using amplicon sequencing (blue line) and serogroup profiling (red line).
Suzanne Crull, Emlyn Hammer, Allison E. Mann, Lauren M. O'Connell, Ashlyn Soule, Elizabeth Griffith, Thomas Blouin, Robin L. Brigmon, Vincent P. Richards   +8 more
wiley   +1 more source

Luminal Phospholipase D Attacks Bacterial Membranes in Dictyostelium discoideum Phagosomes

Molecular Microbiology, Volume 124, Issue 1, Page 54-65, July 2025.
This study shows that PldX, a luminal Phospholipase D, is necessary for the efficient destruction of ingested Klebsiella pneumoniae bacteria in Dictyostelium discoideum phagosomes. PldX and the AlyL lysozyme together attack the bacterial membrane and permeabilize it. To date, the molecular substrate of PldX remains to be determined. ABSTRACT Phagocytic
Otmane Lamrabet, Raphael Munoz‐Ruiz, Imen Ayadi, Alixia Bourbon, Erwann Pain, Joseph Oddy, Pierre Cosson   +6 more
wiley   +1 more source

Eukaryote‐Wide Distribution of a Family of Longin Domain‐Containing GAP Complexes for Small GTPases

Traffic, Volume 26, Issue 7-9, July/September 2025.
The three longin domain‐containing GAP complexes ‐ CSW, folliculin, and GATOR1 ‐ have a sporadic but pan‐eukaryotic distribution and were likely already present in LECA in some form. Their catalytic longin domains contain highly conserved sequence motifs, some of which are shared with structurally similar proteins of Asgardarchaeota.
Anna M. G. Novák Vanclová, Catherine L. Jackson, Joel B. Dacks   +2 more
wiley   +1 more source

The role of Src kinase in the biology and pathogenesis of Acanthamoeba castellanii

Parasites & Vectors, 2012
Background Acanthamoeba species are the causative agents of fatal granulomatous encephalitis in humans. Haematogenous spread is thought to be a primary step, followed by blood–brain barrier penetration, in the transmission of Acanthmaoeba into the ...
Siddiqui Ruqaiyyah, Iqbal Junaid, Maugueret Marie-josée, Khan Naveed   +3 more
doaj   +1 more source

Rare Infectious Diseases: Detection and Clinical Implications

iLABMED, Volume 3, Issue 2, Page 148-157, June 2025.
Rare infectious diseases are infections that are uncommon, have a low incidence, and are caused by newly emerging pathogens, cross‐species or ectopic infections, or host immunodeficiencies. The detection and diagnosis of rare infections is one of the main reasons for misdiagnosis and missed diagnosis.
Xin Qian, Yuxin Zhang, Yilin Ye, Qiange Lin, Junyou Lin, Xinrong Lu, Li Chen, Guiqin Sun   +7 more
wiley   +1 more source

Characterizing clinical isolates of Acanthamoeba castellanii with high resistance to polyhexamethylene biguanide in Taiwan

Journal of Microbiology, Immunology and Infection, 2017
Background/Purpose: Acanthamoeba keratitis (AK), a painful infectious corneal disease, is caused by the free-living pathogenic species Acanthamoeba. The symptoms include corneal infiltrate, epithelial, and stromal destruction, and loss of vision. Current
Fu-Chin Huang, Min-Hsiu Shih, Kai-Fei Chang, Jian-Ming Huang, Jyh-Wei Shin, Wei-Chen Lin   +5 more
doaj   +1 more source

Antiamoebic activity of plant-based natural products and their conjugated silver nanoparticles against Acanthamoeba castellanii (ATCC 50492)

AMB Express, 2020
Acanthamoeba spp. are the causative agent of Acanthamoeba keratitis and granulomatous amoebic encephalitis (GAE). The current options to treat Acanthamoeba infections have limited success.
Areeba Anwar, Elaine Lim Siew Ting, Ayaz Anwar, Noor ul Ain, Shaheen Faizi, Muhammad Raza Shah, Naveed Ahmed Khan, Ruqaiyyah Siddiqui   +7 more
doaj   +1 more source

In Vitro Effect of Pitavastatin and Its Synergistic Activity with Isavuconazole against Acanthamoeba castellanii

Pathogens, 2020
Acanthamoeba keratitis (AK) can occur in healthy individuals wearing contact lenses and it is a painful, blinding infection of the cornea caused by a free-living ameba Acanthamoeba.
Hye Jee Hahn, Jose Ignacio Escrig, Brian Shing, Anjan Debnath   +3 more
doaj   +1 more source

Effect of Nitric Oxide onAcanthamoeba castellanii

Investigative Opthalmology & Visual Science, 2018
Acanthamoeba keratitis is a well-known intractable corneal infectious disease. We investigated the anti-Acanthamoeba effect of exogenous nitric oxide (NO).Acanthamoeba castellanii was axenically cultured and exposed to various concentrations of NO donors, such as sodium nitrite, sodium nitroprusside (SNP), and NO-releasing silica nanoparticles (coated ...
Bora, Yim, Joo-Hee, Park, Hyejoong, Jeong, Jinkee, Hong, Martha, Kim, Minwook, Chang, Roy S, Chuck, Choul Yong, Park   +7 more
openaire   +2 more sources