Results 61 to 70 of about 3,715 (174)

PLASMA AND PHAGOSOME MEMBRANES OF ACANTHAMOEBA CASTELLANII [PDF]

The Journal of Cell Biology, 1971
Plasma membranes were isolated from the ameba Acanthamoeba castellanii by low-speed velocity centrifugation followed by equilibrium centrifugation in a sucrose gradient. The isolated membranes had a high ratio of sterol to phospholipid (0.98 moles/mole) and of phospholipid to protein (0.43 mg/mg). The plasma membranes had very low concentrations of DNA,
A G, Ulsamer, P L, Wright, M G, Wetzel, E D, Korn   +3 more
openaire   +2 more sources

Repurposing Drugs as Bacteroides fragilis BFT‐3 Inhibitors in the Animal Infection Model Galleria mellonella

Annals of the New York Academy of Sciences, Volume 1557, Issue 1, March 2026.
This work establishes a newly developed Galleria mellonella infection model as a powerful, ethical platform for studying Bacteroides fragilis pathogenesis and therapy. Leveraging this model, the study identifies MOA4 as a potent BFT‐3 inhibitor that improves host survival, increases bacterial clearance, and synergizes with antibiotics without toxicity.
Ana Jiménez‐Alesanco, Marta Gómara‐Lomero, Hajar Jeblaoui, Sonia Vega, Adrián Velázquez‐Campoy, José Antonio Aínsa, Olga Abián   +6 more
wiley   +1 more source

Cellular Coordination of Transcription Factors and Regulatory Genes for Cryptococcal Virulence

Cellular Microbiology, Volume 2026, Issue 1, 2026.
Cryptococcus neoformans is an opportunistic pathogen belonging to the family Cryptococcaceae, capable of causing systemic and invasive fungal infections in humans and animals. The infection caused by Cryptococcus is lethal primarily in immunocompromised individuals due to the overwhelming expression of virulence factors that drive cryptococcosis in ...
Olufemi S. Folorunso, Olihile M. Sebolai, Sanket Kaushik   +2 more
wiley   +1 more source

Essential Role for an M17 Leucine Aminopeptidase in Encystation of Acanthamoeba castellanii. [PDF]

PLoS ONE, 2015
Encystation of Acanthamoeba leads to the formation of resilient cysts from vegetative trophozoites. This process is essential for parasite survival under unfavorable conditions such as starvation, low temperatures, and exposure to biocides.
Yu-Ran Lee, Byoung-Kuk Na, Eun-Kyung Moon, Su-Min Song, So-Young Joo, Hyun-Hee Kong, Youn-Kyoung Goo, Dong-Il Chung, Yeonchul Hong   +8 more
doaj   +1 more source

Isolation and Molecular Identification of Potentially Pathogenic Free‐Living Amoeba in Tap Water Faucets in Quezon City, Philippines

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
Free‐living amoebae (FLA) are ubiquitous in environmental water and soil, and their presence in water systems for human consumption is a public health concern due to their potential pathogenicity and ability to act as a reservoir for pathogenic bacteria.
Jehudiel Eugenio R. Tiglao, Davin Edric V. Adao, Satabdi Datta Choudhury   +2 more
wiley   +1 more source

The role of proteases in the differentiation ofAcanthamoeba castellanii [PDF]

FEMS Microbiology Letters, 2008
Proteases are significant determinants of protozoan pathogenicity and cytolysis of host cells. However, there is now growing evidence of their involvement in cellular differentiation. Acanthamoeba castellanii of the T4 genotype elaborates a number of proteases, which are inhibited by the serine protease inhibitor phenylmethylsulphonyl fluoride.
Dudley, R, Alsam, S, Khan, NA
openaire   +3 more sources

Database Release: PPSDB, a Linked Open Data Knowledge Base for Protist–Prokaryote Symbioses

Journal of Eukaryotic Microbiology, Volume 72, Issue 6, November/December 2025.
ABSTRACT As the ecological and evolutionary importance of symbiotic interactions between protists (microbial eukaryotes) and prokaryotes (bacteria and archaea) is better appreciated, keeping an overview of their diversity and the literature becomes a growing and ongoing challenge.
Brandon K. B. Seah
wiley   +1 more source

Adhesion forces and mechanics in mannose-mediated acanthamoeba interactions. [PDF]

PLoS ONE, 2017
The human pathogenic amoeba Acanthamoeba castellanii (A. castellanii) causes severe diseases, including acanthamoeba keratitis and encephalitis. Pathogenicity arises from the killing of target-cells by an extracellular killing mechanism, where the ...
Steven Huth, Julia F Reverey, Matthias Leippe, Christine Selhuber-Unkel   +3 more
doaj   +1 more source

In Vitro Study on the Efficacy of Ziziphus vulgaris L. and Camellia sinensis (L.) Kuntze Extracts for Controlling Varroa destructor (Acari: Varroidae) in Apis mellifera (Hym.: Apidae)

Veterinary Medicine and Science, Volume 11, Issue 5, September 2025.
Extracts of Ziziphus vulgaris and Camellia sinensis applied in wooden cages increase Varroa destructor mortality (5–25 µL/L air) while minimizing Apis mellifera harm, offering a sustainable mite control method. ABSTRACT Background Ziziphus vulgaris L.
Salim Ojagh, Farnaz Malekifard, Mohammad Yakhchali   +2 more
wiley   +1 more source

Novel insights into the potential role of ion transport in sensory perception in Acanthamoeba

Parasites & Vectors, 2019
Background Acanthamoeba is well known to produce a blinding keratitis and serious brain infection known as encephalitis. Effective treatment is problematic, and can continue up to a year, and even then, recurrence can ensue.
Ruqaiyyah Siddiqui, Stephen K. Roberts, Timothy Yu Yee Ong, Mohammad Ridwane Mungroo, Areeba Anwar, Naveed Ahmed Khan   +5 more
doaj   +1 more source