Results 41 to 50 of about 5,263 (211)

Antiamoebic Properties of Ceftriaxone and Zinc-Oxide–Cyclodextrin-Conjugated Ceftriaxone

open access: yesAntibiotics, 2022
Acanthamoeba castellanii is a ubiquitous free-living amoeba capable of instigating keratitis and granulomatous amoebic encephalitis in humans. Treatment remains limited and inconsistent.
Zinb Makhlouf   +6 more
doaj   +1 more source

Acanthamoeba castellanii induces host cell death via a phosphatidylinositol 3-kinase-dependent mechanism

open access: yes, 2005
Granulomatous amoebic encephalitis due to Acanthamoeba castellanii is a serious human infection with fatal consequences, but it is not clear how the circulating amoebae interact with the blood-brain barrier and transmigrate into the central nervous ...
S. Jayasekera   +11 more
core   +1 more source

Induced encystment improves resistance to preservation and storage of Acanthamoeba castellanii

open access: yes, 2008
Several conditions that allow the preservation, storage and rapid, efficient recovery of viable Acanthamoeba castellanii organisms were investigated. The viability of trophozoites (as determined by time to confluence) significantly declined over a period
Campbell, S. J.   +7 more
core   +1 more source

Characterisation of sterol biosynthesis and validation of 14α-demethylase as a drug target in Acanthamoeba

open access: yesScientific Reports, 2017
The soil amoebae Acanthamoeba causes Acanthamoeba keratitis, a severe sight-threatening infection of the eye and the almost universally fatal granulomatous amoebic encephalitis. More effective treatments are required.
Scott Thomson   +5 more
doaj   +1 more source

In Vitro Effectiveness of Soft Contact Lens Solutions Available on the Dutch Market against Acanthamoeba Species

open access: yesPathogens, 2023
Acanthamoeba keratitis is almost universally associated with contact lens (CL) use. Until today, however, CL solution manufacturing protocols lack testing of anti-amoebic activity.
Anna C. Randag   +7 more
doaj   +1 more source

Effects of Mannose on Pathogenesis of Acanthamoeba castellanii

open access: yesThe Korean Journal of Parasitology, 2012
Acanthamoeba spp. are single-celled protozoan organisms that are widely distributed in the environment. In this study, to understand functional roles of a mannose-binding protein (MBP), Acanthamoeba castellanii was treated with methyl-alpha-D-mannopyranoside (mannose), and adhesion and cytotoxicity of the amoeba were analyzed.
Yoo, Kyung-Tae, Jung, Suk-Yul
openaire   +2 more sources

Acanthamoeba induces cell-cycle arrest in host cells

open access: yes, 2004
Acanthamoeba can cause fatal granulomatous amoebic encephalitis (GAE) and eye keratitis. However, the pathogenesis and pathophysiology of these emerging diseases remain unclear.
Alsam, S.   +5 more
core   +1 more source

Ac-HSP20 Is Associated With the Infectivity and Encystation of Acanthamoeba castellanii

open access: yesFrontiers in Microbiology, 2021
Acanthamoeba castellanii is a pathogenic and opportunistic free-living amoeba that causes Acanthamoeba keratitis (AK) and granulomatous amebic encephalitis (GAE) in immunocompromised individuals.
Ningning Wang   +8 more
doaj   +1 more source

Acanthamoeba castellanii, a Predator of Cyanobacteria [PDF]

open access: yesMicrobiology, 1981
Acanthamoeba castellanii was isolated from soil and water as a predator of cyanobacteria. Several strains of A. castellanii consumed cyanobacteria but there were differences in predatory activity between strains. The unicellular Gloeocapsa alpicola and filamentous Anabaena flos-aquae were particularly susceptible to predation.
S. J. L. WRIGHT, K. REDHEAD, H. MAUDSLEY
openaire   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, Volume 600, Issue 10, Page 1491-1518, May 2026.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

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