Results 131 to 140 of about 2,893 (176)
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Journal of Cutaneous Pathology, 1993
The incidental finding of microscopic foci of acantholytic dyskeratosis, reproducing the histological pattern of Darier's disease, has been the subject of a number of papers in the last few years. In contrast, the incidental finding of other types of acantholysis has not been mentioned in the literature.
E, Sánchez Yus +3 more
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The incidental finding of microscopic foci of acantholytic dyskeratosis, reproducing the histological pattern of Darier's disease, has been the subject of a number of papers in the last few years. In contrast, the incidental finding of other types of acantholysis has not been mentioned in the literature.
E, Sánchez Yus +3 more
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Enzymes, Acantholysis, and Pemphigus
Archives of Dermatology, 1962The mechanical basis of acantholysis is the loss of both structure and function of the intercellular bridges (desmosomes) which connect certain epithelial cells. Using electron microscopy, Wilgram, Caulfield, and Lever 1 have recently provided evidence that this is a result of intracellular damage in epithelial cells.
D R, WEAKLEY, J M, EINBINDER
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International Journal of Dermatology, 2000
Abstract Background Exogenous factors, such as certain drugs, may be involved in the induction of pemphigus. Other offenders sharing a similar chemical composition to these drugs may also play a role. Tannins with their considerable biologic activity were suggested as possible factors.
BRENNER S +6 more
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Abstract Background Exogenous factors, such as certain drugs, may be involved in the induction of pemphigus. Other offenders sharing a similar chemical composition to these drugs may also play a role. Tannins with their considerable biologic activity were suggested as possible factors.
BRENNER S +6 more
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In vitro Acantholysis by Captopril and Thiopronine
Dermatologica, 2009The possible acantholytic property of captopril and thiopronine has been investigated using in vitro tissue cultures. Normal human breast skin explants have been cultured in Hanks’ balanced salt solution containing 40% normal inactivated human serum with the addition of L-cysteine, or reduced glutathione (GSH), or captopril, or thiopronine, at four ...
RUOCCO, Vincenzo +3 more
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In vivo Enalapril-Induced Acantholysis
Dermatology, 1999Enalapril is a widely used antihypertensive drug with a very powerful in vitro acantholytic effect. It has been known to potentially induce pemphigus in genetically predisposed subjects. The action mechanism is complex and still only partially understood.
LO SCHIAVO, Ada +5 more
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Journal of Clinical Immunology, 1984
Many studies have shown that human skin in organ cultures containing pemphigus antibody undergoes acantholysis, the histologic hallmark of pemphigus vulgaris. This in vitro organ culture system provides a good model to determine if drugs used to treat pemphigus inhibit the effect of pemphigus antibody after it is produced.
E W, Jeffes, R P, Kaplan, A R, Ahmed
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Many studies have shown that human skin in organ cultures containing pemphigus antibody undergoes acantholysis, the histologic hallmark of pemphigus vulgaris. This in vitro organ culture system provides a good model to determine if drugs used to treat pemphigus inhibit the effect of pemphigus antibody after it is produced.
E W, Jeffes, R P, Kaplan, A R, Ahmed
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Observations on the Biochemical Genesis of Acantholysis
Archives of Dermatology, 1961Cantharidin is the vesicating agent of the beetle Canthus vesicatoria. Auspitz described the histopathology of such blisters in 1883,1and Miescher later confirmed his findings.2The major changes seen in the epidermis are spongiosis, vesiculation, and acantholysis.
D R, WEAKLEY, J M, EINBINDER
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Mechanisms of Acantholysis in Pemphigus Foliaceus
Clinical Immunology and Immunopathology, 1997Pemphigus foliaceus (PF) is a dermatosis characterized by subcorneal vesicles and pathogenic IgG autoantibodies against desmoglein 1. PF IgG passively transferred into neonatal mice induces a blistering disease that duplicates the key findings of PF. In this study we have used this animal model to investigate the role of complement and IgG valence in ...
A, España +6 more
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Pityriasis rubra pilaris with acantholysis
Journal of Cutaneous Pathology, 1996Two patients* developed a papulosquamous eruption in a widespread distribution which progressed with islands of sparing of uninvolved skin characteristic clinically of adult‐onset pityriasis rubra pilaris (PRP). Biopsies from both patients showed multiple areas of nonfollicular and follicular suprabasilar and intra‐epidermal acantholysis with minimal ...
K, Howe +3 more
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Apoptosis is not required for acantholysis in pemphigus vulgaris
American Journal of Physiology-Cell Physiology, 2009The autoimmune blistering skin disease pemphigus vulgaris (PV) is caused primarily by autoantibodies against desmosomal cadherins. It was reported that apoptosis can be detected in pemphigus skin lesions and that apoptosis can be induced by PV-IgG in cultured keratinocytes.
Enno, Schmidt +5 more
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