Results 1 to 10 of about 4,589 (188)

Case Report: Persistent toxic reactions in a toddler with a negative blood cantharidin toxicology test [PDF]

Frontiers in Pediatrics
Cantharidin is a potent natural toxin and has been used in traditional Chinese medicine to treat cancers and various ailments such as rabies or psoriasis. However, improper use of cantharidin can easily lead to poisoning.
Zhuyan Duan, Yanning Qu, Rui Tang, Mengyi Sheng, Liangliang Wang, Jiao Li, Si Zheng, Linying Guo   +7 more
doaj   +3 more sources

Cantharidin: a double-edged sword in medicine and toxicology [PDF]

Frontiers in Pharmacology
Cantharidin (CTD), a natural terpenoid toxin secreted by blister beetles, acts as a potent inhibitor of protein phosphatase. As the principal active component of Mylabris, a traditional Chinese medicine, CTD has attracted considerable interest due to its
Jie Zhang, Tongtong Tian, Canyu Li, Yong Liu, Yunyun Wang, Ling Liu, Liang Liu, Yufeng Yao   +7 more
doaj   +3 more sources

Cantharidin overcomes IL-2Rα signaling-mediated vorinostat resistance in cutaneous T-cell lymphoma through reactive oxygen species [PDF]

Journal for ImmunoTherapy of Cancer
Background Vorinostat (SAHA) is a histone deacetylase inhibitor that has shown clinical efficacy against advanced cutaneous T-cell lymphoma (CTCL). However, only a subset of patients with CTCL (30–35%) respond to SAHA and the response is not always ...
Hongmei Zhang, Man Zhu, Wenjun Tang, Xiaoyu Tang, Zeren Zhu, Yina Jiang, Ammar Sarwar, Dake Chu, Zixi Zhang, Yanmin Zhang   +9 more
doaj   +3 more sources

Anticancer Attributes of Cantharidin: Involved Molecular Mechanisms and Pathways

Molecules, 2020
Cancer is a preeminent threat to the human race, causing millions of deaths each year on the Earth. Traditionally, natural compounds are deemed promising agents for cancer treatment.
Yu Changyuan, Yixin Wu
exaly   +4 more sources

On the history, synthesis, and medicinal use of cantharidin, LB-100, and their analogs. [PDF]

RSC Med Chem
Cantharidin, a defensive toxin produced by blister beetles, has fascinated chemists, physicians, and historians for centuries. From its notorious use as the aphrodisiac “Spanish fly” to its modern FDA approval as YCANTH™ for molluscum contagiosum, this ...
Scott KA, McCluskey A, Njardarson JT, Wang W.   +3 more
europepmc   +2 more sources

Cantharidin induces apoptosis of human triple negative breast cancer cells through mir-607-mediated downregulation of EGFR

Journal of Translational Medicine, 2023
Background Triple negative breast cancer (TNBC) is a major subtype of breast cancer, with limited therapeutic drugs in clinical. Epidermal growth factor receptor (EGFR) is reported to be overexpressed in various TNBC cells.
Tianfeng Yang, Runze Yu, Cheng Cheng, Jian Huo, Zhengyan Gong, Hanbing Cao, Yu Hu, Bingling Dai, Yanmin Zhang   +8 more
doaj   +2 more sources

Cantharidin-Loaded Nanomedicine Modified with Amphiphilic Peptides Induce Immunogenic Cell Death to Enhance PD-1 Blockade. [PDF]

ACS Appl Mater Interfaces
Recent advances in immune checkpoint inhibitors (ICIs), particularly those targeting PD-1/PD-L1, have transformed cancer treatment. However, their efficacy is often hampered by the immunosuppressive tumor microenvironment (TME).
Tang Y, Jiang Q, Chen R, Wu S, Luo Y, Huang X, Yu G, Shao C.   +7 more
europepmc   +2 more sources

Effects of Cantharidin on Fish Erythrocytes, Tumor Cell Lines, and Marine Pathogenic Bacteria

Fishes, 2023
Cantharidin, a toxic monoterpene secreted by blister beetles, has long been used in traditional Chinese and modern medicine for its unique properties. However, despite its widespread use, its effects on fish have not been studied.
Jose Carlos Campos-Sánchez, Francisco A. Guardiola, María Ángeles Esteban   +2 more
doaj   +2 more sources

Functional studies of McSTE24, McCYP305a1, and McJHEH, three essential genes act in cantharidin biosynthesis in the blister beetle (Coleoptera: Meloidae). [PDF]

J Insect Sci
Cantharidin is a toxic defensive substance secreted by most blister beetles when attacked. It has been used to treat many complex diseases since ancient times and has recently regained popularity as an anticancer agent. However, the detailed mechanism of
Huang Y, Shen L, Du F, Wang Z, Yin Y.
europepmc   +2 more sources

Cantharidin and sodium fluoride attenuate the negative inotropic effect of the A₁-adenosine receptor agonist N⁶-(R)-phenylisopropyl adenosine in isolated human atria. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Cantharidin and sodium fluoride inhibit the activity of serine/threonine protein phosphatases 1 (PP1) and 2A (PP2A) and increase the force of contraction in human atrial preparations. R-phenylisopropyl adenosine (R-PIA) acts as an agonist at A1-adenosine
Schwarz R, Hofmann B, Gergs U, Neumann J.   +3 more
europepmc   +2 more sources