Results 101 to 110 of about 9,228,267 (373)

Accelerated aging test in the determination of safflower seeds vigor

Bioscience Journal, 2022
In assessing the quality of seed lots, the vigor tests are complementary to the germination test and they identify differences in the degree of deterioration of the lots. For safflower, there is little information regarding these tests.
Mirelle Vaz Coelho, Ingrid Maressa Hungria de Lima e Silva, Amalia Andreza Sousa Silva, Rogério Borges de Oliveira Paz, Diego Ismael Rocha, Carla Gomes Machado, Givanildo Zildo da Silva   +6 more
doaj   +1 more source

Aging enhances contraction to thromboxane A2 in aorta from female senescence mice [PDF]

, 2013
The time-course for aging-associated effects on vascular reactivity to U46619, a stable analogue of thromboxane A2 (TXA2), was studied in aorta from female senescence-accelerated mice-prone (SAMP8), a murine model of accelerated senescence.
Bueno, C., Dantas, A. P., Heras, Magda, Hermenegildo, Carlos, Medina Bessó, Pascual, Novella del Campo, Susana, Novensá, L., Segarra Irles, Gloria Vicenta   +7 more
core   +2 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

Effect of radiant exposure and UV accelerated aging on physico-chemical and mechanical properties of composite resins

Journal of Applied Oral Science, 2019
Currently, there is no consensus in terms of defining the minimum radiant exposure values necessary for achieving adequate properties of composite resin. In addition, the long-term influence that radiant exposure has on the properties of composite resins
Carlos Enrique Cuevas-Suárez, Carine Tais Walter Meereis, Norma D’accorso, Ricardo Macchi, Adriana Leticia Ancona-Meza, Eliezer Zamarripa-Calderón   +5 more
doaj   +1 more source

Color alteration of the paint used for iris painting in ocular prostheses [PDF]

, 2009
The purpose of this study was to assess color alteration of the paints used for iris painting in artificial eyes. Five disks of heat cured acrylic resin were confectioned by microwave energy for each paint analyzed, in a total of 40 specimens.
Batista, Marcos Antônio Jacó, Fernandes, Aline Úrsula Rocha, Goiato, Marcelo Coelho, Santos, Daniela Micheline dos   +3 more
core   +4 more sources

Obesity accelerates cardiovascular ageing

European Heart Journal
Abstract A global obesity pandemic, coupled with an increasingly ageing population, is exacerbating the burden of cardiovascular disease. Indeed, clinical and experimental evidence underscores a potential connection between obesity and ageing in the pathogenesis of various cardiovascular disorders. This is further supported by the notion
Ruperez, Celia, Madeo, Frank, de Cabo, Rafael, Kroemer, Guido, Abdellatif, Mahmoud   +4 more
openaire   +3 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Blood Biochemistry Analysis to Detect Smoking Status and Quantify Accelerated Aging in Smokers

Scientific Reports, 2019
There is an association between smoking and cancer, cardiovascular disease and all-cause mortality. However, currently, there are no affordable and informative tests for assessing the effects of smoking on the rate of biological aging.
Polina Mamoshina, Kirill Kochetov, Franco Cortese, Anna Kovalchuk, A. Aliper, E. Putin, M. Scheibye-Knudsen, Charles R. Cantor, N. Skjodt, O. Kovalchuk, A. Zhavoronkov   +10 more
semanticscholar   +1 more source