Results 41 to 50 of about 350,386 (298)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Impact of Wetting–Drying Cycles on the Mechanical Properties and Microstructure of Wood Waste–Gypsum Composites [PDF]

, 2019
Large amounts of wood waste are generated each year in the world. In an attempt to identify a good recovery option for those residues, wood waste from construction and demolition works were used as raw materials in gypsum plasters.
Morales Conde, María Jesús, Pedreño-Rojas, M. Alejandro, Pérez Gálvez, Filomena, Rubio de Hita, Paloma   +3 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The Influence of Junction Temperature Variation of LED on the Lifetime Estimation During Accelerated Aging Test

IEEE Access, 2019
In this paper, seven LED lamps are selected to investigate how the junction temperature (Tj) of LED varies during the step-stress temperature accelerated aging test. The ambient temperatures are 80 °C and 70 °C for the first and second step
Xiao-Xun Wang, Lei Jing, Yao Wang, Qun Gao, Qiang Sun   +4 more
doaj   +1 more source

Probabilistic Monte-Carlo method for modelling and prediction of electronics component life [PDF]

, 2014
Power electronics are widely used in electric vehicles, railway locomotive and new generation aircrafts. Reliability of these components directly affect the reliability and performance of these vehicular platforms.
Alghassi, Ali, Perinpanayagam, Suresh, Sreenuch, T., Xie, Ye   +3 more
core   +1 more source

Obesity May Accelerate the Aging Process [PDF]

Frontiers in Endocrinology, 2019
Lines of evidence from several studies have shown that increases in life expectancy are now accompanied by increased disability rate. The expanded lifespan of the aging population imposes a challenge on the continuous increase of chronic disease. The prevalence of overweight and obesity is increasing at an alarming rate in many parts of the world ...
Salvestrini V., Sell C., Lorenzini A.
openaire   +3 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

An alternative methodology to predict aging effects on the mechanical properties of glass fiber reinforced cement (GRC) [PDF]

, 2012
The effect of three different aging methods (immersion in hot water, freeze–thaw cycles and wet–dry cycles) on the mechanical properties of GRC were studied and compared.
Enfedaque Díaz, Alejandro, Sanchez Galvez, Vicente, Sanchez Paradela, Laura   +2 more
core   +3 more sources

The emerging role of cellular senescence in renal diseases [PDF]

, 2020
Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco, Chen, Rong, Francis, Heather, Glaser, Shannon, Li, Siwen, Li, Xuesen, Meng, Fanyin, Wan, Ying, Wu, Nan, Zhang, Chunmei, Zhou, Bingru, Zhou, Tianhao, Zou, Ping   +12 more
core   +1 more source

Anxiety disorders and accelerated cellular ageing [PDF]

British Journal of Psychiatry, 2015
BackgroundAnxiety disorders increase the risk of onset of several ageing-related somatic conditions, which might be the consequence of accelerated cellular ageing.AimsTo examine the association between anxiety status and leukocyte telomere length (LTL) as an indicator of cellular ageing.MethodData are from individuals with current (n = 1283) and ...
Verhoeven, Josine E., Revesz, Dora, van Oppen, Patricia, Epel, Elissa S., Wolkowitz, Owen M., Penninx, Brenda W.   +5 more
openaire   +5 more sources