Results 51 to 60 of about 10,649,676 (300)

ON RADIATION-INDUCED AGING: ACCELERATED OR PREMATURE AGING

Radiation Protection Dosimetry, 2022
Abstract The concept of radiation-induced aging is revisited from the viewpoint of a mathematical model. The effect of radiation on carcinogenesis is treated based on the Armitage–Doll multi-stage theory. The formula obtained for cancer incidence rate indicates that radiation dose can be explained in terms of time.
Takahiro Wada, Tetsuhiro Kinugawa, Satoshi Tanaka   +2 more
openaire   +2 more sources

Effect of stress relaxation on accelerated physical aging of hydrogenated nitrile butadiene rubber using time-temperature-strain superposition principle

Advanced Industrial and Engineering Polymer Research, 2019
While the stress relaxation is a common phenomenon for polymers, its effect on the stress/strain accelerated aging of the hydrogenated nitrile butadiene rubber (HNBR) cannot be ignored.
Qidi Peng, Zhongmeng Zhu, Chengkai Jiang, Han Jiang   +3 more
doaj   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Melatonin inhibits cytosolic mitochondrial-DNA induced neuroinflammatory signaling in accelerated aging and neurodegeneration.

Journal of Clinical Investigation, 2020
Chronic inflammation is a pathologic feature of neurodegeneration and aging; however, the mechanism regulating this process is not understood. Melatonin, an endogenous free radical scavenger synthesized by neuronal mitochondria, decreases with aging and ...
A. Jauhari, Sergei V. Baranov, Y. Suofu, Jinho Kim, Tanisha Singh, S. Yablonska, Fang Li, Xiaomin Wang, Patrick J. Oberly, M. B. Minnigh, S. Poloyac, D. Carlisle, Robert M. Friedlander   +12 more
semanticscholar   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

Mitochondrial Dysfunction Accelerates Ageing

Immunometabolism, 2020
Abstract We review here the seminal findings of Desdin-Mico et al. showing that T cells with dysfunctional mitochondria induce multimorbity and premature senescence, due to mitochondrial transcription factor A (TFAM). They add further weight to the idea that targeting immunometabolism could be beneficial in combating the ...
Schroth, J, Henson, SM
openaire   +3 more sources

Telomerase Protects Werner Syndrome Lineage-Specific Stem Cells from Premature Aging

Stem Cell Reports, 2014
Werner syndrome (WS) patients exhibit premature aging predominantly in mesenchyme-derived tissues, but not in neural lineages, a consequence of telomere dysfunction and accelerated senescence.
Hoi-Hung Cheung, Xiaozhuo Liu, Lucile Canterel-Thouennon, Lu Li, Catherine Edmonson, Owen M. Rennert   +5 more
doaj   +1 more source

Cross-linking density and aging constitutive model of HTPB coating under prestrain thermal accelerated aging

Defence Technology, 2020
In order to study the cross-linking density and aging constitutive relationship of HTPB coating during storage, the thermal accelerated aging tests at 0%, 3%, 6% and 9% prestrains were carried out.
Yong-qiang Du, Jian Zheng, Chao Xiong
doaj   +1 more source

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

Nature Communications, 2019
Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. WS patients exhibit severe metabolic phenotypes, but the underlying mechanisms are
E. Fang, Yujun Hou, Sofie Lautrup, M. B. Jensen, Beimeng Yang, T. Sengupta, D. Caponio, Rojyar Khezri, Tyler G. Demarest, Yahyah Aman, D. Figueroa, M. Morevati, Ho-Joon Lee, Hisaya Kato, H. Kassahun, Jong-Hyuk Lee, Deborah Filippelli, M. Okur, A. Mangerich, D. Croteau, Y. Maezawa, C. Lyssiotis, J. Tao, K. Yokote, T. Rusten, M. Mattson, Heinrich Jasper, H. Nilsen, V. Bohr   +28 more
semanticscholar   +1 more source

Accelerated aging among childhood, adolescent, and young adult cancer survivors is evidenced by increased expression of p16INK4a and frailty

Cancer, 2020
Cellular senescence, measured by expression of the cell cycle kinase inhibitor p16INK4a, may contribute to accelerated aging in survivors of childhood, adolescent, and young adult cancer.
Andrew B. Smitherman, W. Wood, N. Mitin, Vanessa Ayer Miller, A. Deal, I. Davis, J. Blatt, S. Gold, H. Muss   +8 more
semanticscholar   +1 more source