Results 51 to 60 of about 979,081 (252)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Accelerated aging test to evaluate of physiological potential in coriander seeds

Semina: Ciências Agrárias, 2015
The vigor tests are essential in programs of quality control of seeds, and the accelerated aging test is one which can be used for this purpose. In this sense, this paper aimed to study the methodology of the accelerated aging test, in order to identify ...
Maria Francisca Soares Pereira , Salvador Barros Torres , Paulo César Ferreira Linhares   +2 more
doaj   +1 more source

The accelerated aging model reveals critical mechanisms of late-onset Parkinson’s disease

BioData Mining, 2020
Background Late-onset Parkinson’s disease (LOPD) is a common neurodegenerative disorder and lacks disease-modifying treatments, attracting major attentions as the aggravating trend of aging population.
Shiyan Li, Hongxin Liu, Shiyu Bian, Xianzheng Sha, Yixue Li, Yin Wang   +5 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Interpretable machine learning with SHAP analysis identifies redox-modulating dietary antioxidants for predicting accelerated biological aging

Experimental Gerontology
Background: Aging is a complex biological process characterized by progressive functional decline across multiple physiological systems, and biological age provides a more accurate reflection of an individual's aging status than chronological age ...
Bei Zhang, Xinyu Zhang, Lanyue Ma, Danfei Li, Yijia Li, Sen Lin, Lisheng Peng, Li He   +7 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Media use and well-being in older adults: The mediating role of social inclusion and subjective accelerated aging

International Psychogeriatrics
Aims: With the rise in global life expectancy, interest in older adults’ mental well-being is growing. Media use is currently seen as potentially contributing to well-being.
Naama Nebenzahl-Elitzur, MSW, Maya Kagan, Professor, Ester Zychlinski, Professor   +2 more
doaj   +1 more source

Effects of Accelerated Aging and Acid Scarification of Seed Coat with Hydrochloric Acid on Seed Germination Characteristics of Chickpea c.v. Kaka [PDF]

Ikufīziyuluzhī-i Giyāhān-i Zirā̒ī, 2014
To evaluate the effects of accelerated aging and seed coat scarification with Hydrochloric acid (HCl) on seed germination characteristics of chickpea (Cicer arietinum) c.v.
R. Sadrabadi Haghighi
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source