Results 71 to 80 of about 10,649,676 (300)

Accelerated aging in the brain, epigenetic aging in blood, and polygenic risk for schizophrenia

medRxiv, 2020
Schizophrenia patients show signs of accelerated aging in cognitive and physiological domains. Both schizophrenia and accelerated aging, as measured by MRI brain images and epigenetic clocks, are correlated with increased mortality.
J. Teeuw, A. Ori, R. Brouwer, S. D. de Zwarte, H. Schnack, H. Pol, R. Ophoff   +6 more
semanticscholar   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The Influence of Junction Temperature Variation of LED on the Lifetime Estimation During Accelerated Aging Test

IEEE Access, 2019
In this paper, seven LED lamps are selected to investigate how the junction temperature (Tj) of LED varies during the step-stress temperature accelerated aging test. The ambient temperatures are 80 °C and 70 °C for the first and second step
Xiao-Xun Wang, Lei Jing, Yao Wang, Qun Gao, Qiang Sun   +4 more
doaj   +1 more source

Association Between Elevated suPAR, a New Biomarker of Inflammation, and Accelerated Aging

The journals of gerontology. Series A, Biological sciences and medical sciences, 2020
Background To understand and measure the association between chronic inflammation, aging, and age-related diseases, broadly applicable standard biomarkers of systemic chronic inflammation are needed.
L. Rasmussen, A. Caspi, Antony Ambler, A. Danese, Maxwell Lorenz Elliott, J. Eugen-Olsen, A. Hariri, H. Harrington, R. Houts, R. Poulton, S. Ramrakha, K. Sugden, Benjamin S. Williams, T. Moffitt   +13 more
semanticscholar   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Some molecular-genetic determinants of premature aging in women

Consilium Medicum
Background. Accelerated biological aging is associated with age-related diseases and an increased risk of mortality. Genetic predisposition may be an important factor in this process. Aim.
Elena V. Kudryavtseva, Dinara A. Berezina, Daniil O. Kornilov, Veronika M. Simarzina, Mikhail A. Tryapitsyn, Aleksey A. Bekhter, Vladislav V. Kovalev, Danila L. Zornikov   +7 more
doaj   +1 more source

Down syndrome, accelerated aging and immunosenescence

Seminars in Immunopathology, 2020
Down syndrome is the most common chromosomal disorder, associated with moderate to severe intellectual disability. While life expectancy of Down syndrome population has greatly increased over the last decades, mortality rates are still high and subjects ...
Noémie Gensous, M. Bacalini, C. Franceschi, P. Garagnani   +3 more
semanticscholar   +1 more source

Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

Nature Communications, 2021
Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently develop Alzheimer’s disease (AD) dementia. This impairment may be leveraged to aid investigation of the pre-clinical phase of AD.
J. Gonneaud, A. Baria, A. Pichet Binette, Brian A. Gordon, J. Chhatwal, C. Cruchaga, M. Jucker, J. Levin, S. Salloway, M. Farlow, S. Gauthier, T. Benzinger, John C Morris, Randall J. Bateman, J. Breitner, J. Poirier, Étienne Vachon-Presseau, S. Villeneuve, Michael Howard J. Bruce L. Paul Ronald G. Michael Sarah De Weiner Rosen Miller Aisen Thomas Donohue Walter Ge, Michael W. Weiner, H. Rosen, B. Miller, P. Aisen, R. Thomas, M. Donohue, Sarah Walter, D. Gessert, T. Sather, G. Jiminez, Ronald Petersen, C. Jack, M. Bernstein, Bret J. Borowski, J. Gunter, M. Senjem, P. Vemuri, David Jones, K. Kantarci, C. Ward, S. Mason, C. Albers, D. Knopman, K. Johnson, W. Jagust, Susan M. Landau, J. Trojanowki, A. Toga, K. Crawford, S. Neu, L. Beckett, D. Harvey, C. Decarli, R. Green, A. Saykin, T. Foroud, Li Shen, Faber Kelley, Sungeun Kim, K. Nho, M. Farlow, A. Hake, B. Matthews, S. Herring, Cynthia Hunt, N. Cairns, E. Householder, Lisa Taylor Reinwald, L. Shaw, S. Arnold, J. Karlawish, D. Wolk, E. Liu, T. Montine, Nick Fox, Paul Thompson, N. Schuff, R. Koeppe, J. Heidebrink, J. Lord, Normal L. Foster, E. Reiman, Kewei Chen, A. Fleisher, P. Tariot, Stephanie Reeder, C. Mathis, O. Lopez, M. Oakley, D. Simpson, V. Lee, M. Korecka, M. Figurski, S. Potkin, Zaven Kachaturian, Richard Frank, Peter J. Snyder, S. Molchan, J. Kaye, J. Quinn, B. Lind, R. Carter, S. Dolen, L. Schneider, S. Pawluczyk, Mauricio Beccera, L. Teodoro, B. Spann, J. Brewer, H. Vanderswag, R. Doody, J. Meyer, M. Chowdhury, S. Rountree, M. Dang, Y. Stern, L. Honig, K. Bell, John C Morris, B. Ances, M. Carroll, Sue Leon, M. Mintun, S. Schneider, Angela OliverNG, R. Griffith, D. Clark, D. Geldmacher, J. Brockington, E. Roberson, H. Grossman, Effie M. Mitsis, L. deToledo‐Morrell, R. Shah, R. Duara, D. Varon, Maria T. Greig, Peggy Roberts, Marilyn S. Albert, C. Onyike, D. D’Agostino, S. Kielb, J. Galvin, D. Pogorelec, Brittany Cerbone, Christina A. Michel, H. Rusinek, M. D. de Leon, L. Glodzik, S. de Santi, P. Doraiswamy, J. Petrella, T. Wong, Charles D. Smith, G. Jicha, Peter Hardy, P. Sinha, Elizabeth Oates, G. Conrad, A. Porsteinsson, B. Goldstein, K. Martin, K. Makino, M. Ismail, C. Brand, R. Mulnard, G. Thai, Catherine Mc Adams Ortiz, K. Womack, D. Mathews, M. Quiceno, R. D. Arrastia, Richard D. King, Myron Weiner, K. M. Cook, M. Devous, A. Levey, J. Lah, J. Cellar, J. Burns, H. Anderson, R. Swerdlow, L. Apostolova, K. Tingus, E. Woo, D. Silverman, P. Lu, G. Bartzokis, N. R. G. Radford, Francine ParfittH, Tracy Kendall, Heather K. Johnson, C. V. van Dyck, R. Carson, M. Macavoy, H. Chertkow, H. Bergman, C. Hosein, S. Black, B. Stefanovic, Curtis Caldwell, G. Hsiung, H. Feldman, B. Mudge, Michele Assaly Past, A. Kertesz, J. Rogers, D. Trost, C. Bernick, D. Munic, D. Kerwin, M. Mesulam, K. Lipowski, Chuang‐Kuo Wu, N. Johnson, C. Sadowsky, Walter Martínez, Teresa Villena, Raymond Scott Turner, K. Johnson, B. Reynolds, R. Sperling, Keith A. Johnson, G. Marshall, Meghan T. Frey, J. Yesavage, Joy Taylor, B. Lane, A. Rosen, J. Tinklenberg, M. Sabbagh, C. Belden, S. Jacobson, Sherye A. Sirrel, N. Kowall, R. Killiany, A. Budson, A. Norbash, P. L. Johnson, T. Obisesan, S. Wolday, Joanne S. Allard, A. Lerner, P. Ogrocki, Leon Hudson, E. Fletcher, Owen Carmichael, J. Olichney, S. Kittur, M. Borrie, T. Lee, R. Bartha, Sterling C. Johnson, S. Asthana, C. Carlsson, S. Potkin, Adrian Preda, D. Nguyen, V. Bates, H. Capote, M. Rainka, D. Scharre, M. Kataki, Anahita Adeli, E. Zimmerman, D. Celmins, Alice D. Brown, G. Pearlson, K. Blank, K. Anderson, R. Santulli, T. Kitzmiller, E. Schwartz, Kaycee M. Sinks, J. Williamson, P. Garg, F. Watkins, Brian L. Ott, H. Querfurth, G. Tremont, S. Salloway, P. Malloy, S. Correia, J. Mintzer, K. Spicer, D. Bachman, E. Finger, S. Pasternak, I. Rachinsky, D. Drost, N. Pomara, R. Hernando, A. Sarrael, S. Schultz, L. Ponto, H. Shim, K. Smith, N. Relkin, G. Chaing, Lisa Raudin, Amanda G. Smith, K. Fargher, B. A. Raj, Ricardo Randy Jacob Tammie Sarah Courtney Susan William (B Allegri Bateman Bechara Benzinger Berman Bodge Bra, R. Allegri, R. Bateman, Jacob Bechara, T. Benzinger, S. Berman, Courtney A. Bodge, S. Brandon, W. Brooks, Jill Buck, V. Buckles, Sochenda Chea, J. Chhatwal, Patricio Chrem, Helena Chui, J. Cinco, Tamara Donahue, Jane Douglas, Noelia Edigo, Nilufer Erekin-Taner, A. Fagan, Martin R. Farlow, Colleen D. Fitzpatrick, Gigi Flynn, E. Franklin, H. Fujii, Cortaiga Gant, S. Gardener, B. Ghetti, A. Goate, Jill S. Goldman, B. Gordon, N. Graff-Radford, Julia D. Gray, Alexander Groves, Jason J Hassenstab, Laura Hoechst-Swisher, D. Holtzman, Russ C. Hornbeck, Siri Houeland DiBari, T. Ikeuchi, S. Ikonomovic, C. Jack, Gina Jerome, Celeste M. Karch, K. Kasuga, T. Kawarabayashi, W. Klunk, R. Koeppe, Elke Kuder-Buletta, C. Laske, Jae-Hong Lee, A. Levey, Ralph M. Martins, N. S. Mason, C. Masters, Denise Maue-Dreyfus, E. McDade, H. Mori, Akem Nagamatsu, Katie Neimeyer, James M. Noble, J. Norton, R. Perrin, M. Raichle, A. Renton, J. Ringman, J. Roh, H. Shimada, Wendy C. Sigurdson, H. Sohrabi, Paige Sparks, Kazushi Suzuki, K. Taddei, Peter Wang, C. Xiong, Xiong Xu, Pierre Véronique Mallar Louis Pierre Alan Serge Rick Yass Bellec Bohbot Chakravarty Collins Etienne Evans Ga, Lune P Bellec, V. Bohbot, M. Chakravarty, Louis Collins, Pierre Etienne, A. Evans, Rick Hoge, Yasser Ituria-Medina, V. Nair, J. Near, Natasha Rajah, P. Rosa-Neto, Christine L. Tardif, J. Tremblay-Mercier, Étienne Vachon-Presseau   +394 more
semanticscholar   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A rapid and sensitive method to assess seed longevity through accelerated aging in an invasive plant species

Plant Methods, 2020
Background Seed longevity and vigor assessment is crucial for efficient ex situ biodiversity conservation in genebanks but may also have potential applications for the understanding of ecological processes and in situ biodiversity conservation.
E. Fenollosa, Laia Jené, S. Munné‐Bosch   +2 more
semanticscholar   +1 more source