Results 51 to 60 of about 350,386 (298)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Evolution of free radicals in ultra-high molecular weight polyethylene irradiated by an electron beam during accelerated aging process

Fushe yanjiu yu fushe gongyi xuebao
Irradiated medical ultra-high molecular-weight polyethylene (UHMWPE) must be validated through accelerated aging tests to meet the requirements for implantation into the human body.
WANG Jing, LU Manli, SHEN Rongfang, WANG Mouhua, HU Zhijie, ZHANG Wenli   +5 more
doaj   +1 more source

Accelerated aging methodologies for evaluating physiological potential of treated soybean seeds

Journal of Seed Science, 2021
: This work evaluated the efficiency of accelerated aging test to determine the physiological potential in treated soybean seeds with fungicides and insecticides, in addition to analyzing the concordance between the results obtained by different ...
Rayssa Fernanda dos Santos, Henrique Fabrício Placido, Leonardo Lemes Bosche, Hugo Zeni Neto, Fernando Augusto Henning, Alessandro Lucca Braccini   +5 more
doaj   +1 more source

Mechanical Deformation Accelerates Protein Ageing

Angewandte Chemie, 2017
AbstractA hallmark of tissue ageing is the irreversible oxidative modification of its proteins. We show that single proteins, kept unfolded and extended by a mechanical force, undergo accelerated ageing in times scales of minutes to days. A protein forced to be continuously unfolded completely loses its ability to contract by folding, becoming a labile
Jessica Valle‐Orero, Jaime Andrés Rivas‐Pardo, Rafael Tapia‐Rojo, Ionel Popa, Daniel J. Echelman, Shubhasis Haldar, Julio M. Fernández   +6 more
openaire   +4 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Natural and simulated aging of historical glasses [PDF]

, 2017
We thoroughly studied coloured glass tesserae of historical glass windows of the Santi Giovanni e Paolo Church in Venice by means of ESEM and XPS techniques in order to evaluate the weathering mechanisms of the glass surfaces.
Bertoncello, Renzo, Elena, Rebollo
core   +1 more source

Social disadvantage accelerates aging

Nature Medicine
Abstract Social disadvantage, like advanced age, is a risk factor for a broad range of health conditions; however, whether it influences the aging process remains unclear. Here, using a multicohort approach, we investigated the associations of social disadvantage with age-related plasma proteins and age-related diseases.
Kivimäki, M, Pentti, J, Frank, P, Liu, F, Blake, A, Nyberg, ST, Vahtera, J, Singh-Manoux, A, Wyss-Coray, T, Walker, KA, Partridge, L, Lindbohm, JV   +11 more
openaire   +3 more sources

Age-Specific Acceleration of Cancer [PDF]

Current Biology, 2004
One of the great challenges of cancer research is to explain the epidemiological patterns of cancer incidence based on the molecular processes that lead to uncontrolled cellular proliferation. The epidemiological data demonstrate that the age-specific incidence of many cancers increases in an approximately linear way with age when plotted on a log-log ...
openaire   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Factors influencing accelerated aging in patients with type 2 diabetes mellitus and coronary heart disease

Frontiers in Endocrinology
ObjectiveTo investigate the factors influencing accelerated aging in patients with type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD).MethodsA total of 216 patients diagnosed with T2DM and CHD between August 2019 and August 2023 at Xuzhou ...
Zehua Huang, Nana Liu, Shiyi Chen, Zhiren Chen, Peian Wang   +4 more
doaj   +1 more source