Results 51 to 60 of about 354,268 (327)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Accelerated aging test to evaluate of physiological potential in coriander seeds

Semina: Ciências Agrárias, 2015
The vigor tests are essential in programs of quality control of seeds, and the accelerated aging test is one which can be used for this purpose. In this sense, this paper aimed to study the methodology of the accelerated aging test, in order to identify ...
Maria Francisca Soares Pereira , Salvador Barros Torres , Paulo César Ferreira Linhares   +2 more
doaj   +1 more source

The accelerated aging model reveals critical mechanisms of late-onset Parkinson’s disease

BioData Mining, 2020
Background Late-onset Parkinson’s disease (LOPD) is a common neurodegenerative disorder and lacks disease-modifying treatments, attracting major attentions as the aggravating trend of aging population.
Shiyan Li, Hongxin Liu, Shiyu Bian, Xianzheng Sha, Yixue Li, Yin Wang   +5 more
doaj   +1 more source

Subjective accelerated aging moderates the association between COVID-19 health worries and peritraumatic distress among older adults

Cambridge Prisms: Global Mental Health, 2021
Background The present study examined whether subjective accelerated aging moderated the relationship between COVID-19 health worries and COVID-19 peritraumatic distress among older adults. Method The sample consisted of 277 older adults (M = 69.58, s.d.
Lee Greenblatt-Kimron, Lia Ring, Yaakov Hoffman, Amit Shrira, Ehud Bodner, Yuval Palgi   +5 more
doaj   +1 more source

Protective role of female gender in programmed accelerated renal aging in the rat [PDF]

, 2015
The aging kidney exhibits a progressive decline in glomerular filtration rate, accompanied by inflammatory and oxidative damage. We hypothesized that accelerated, age-related progression of renal injury is ovarian hormones-dependant.
Antus, Attia, August, Baiardi, Baylis, Baylis, Baylis, Baylis, Birn, Bongartz, Bongartz, Botev, Colen, Corman, Cornock, Crofton, Dendooven, Elliot, Everitt, Gerondakis, Gerritsen, Gorriz, Hinton, Joles, Joles, Joles, Jung, Koeners, Langley, Langley-Evans, Langley-Evans, Langley-Evans, Lowry, Macova, Mazairac, McGrath, McMullen, McMullen, McMullen, Miyata, Poggio, Potier, Roesch, Rule, Sahajpal, Sahajpal, Sasser, Schreuder, Sherman, Sherman, Swali, Vanhaesebroeck, Vazquez, Wegorzewska, Wiggins, Woods, Wyndham, Yin, Zheng   +58 more
core   +3 more sources

Mechanical Deformation Accelerates Protein Ageing

Angewandte Chemie, 2017
AbstractA hallmark of tissue ageing is the irreversible oxidative modification of its proteins. We show that single proteins, kept unfolded and extended by a mechanical force, undergo accelerated ageing in times scales of minutes to days. A protein forced to be continuously unfolded completely loses its ability to contract by folding, becoming a labile
Jessica Valle‐Orero, Jaime Andrés Rivas‐Pardo, Rafael Tapia‐Rojo, Ionel Popa, Daniel J. Echelman, Shubhasis Haldar, Julio M. Fernández   +6 more
openaire   +4 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Factors influencing accelerated aging in patients with type 2 diabetes mellitus and coronary heart disease

Frontiers in Endocrinology
ObjectiveTo investigate the factors influencing accelerated aging in patients with type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD).MethodsA total of 216 patients diagnosed with T2DM and CHD between August 2019 and August 2023 at Xuzhou ...
Zehua Huang, Nana Liu, Shiyi Chen, Zhiren Chen, Peian Wang   +4 more
doaj   +1 more source

Association between plant-based dietary pattern and biological aging trajectory in a large prospective cohort

BMC Medicine, 2023
Background Aging is a dynamic and heterogeneous process that may better be captured by trajectories of aging biomarkers. Biological age has been advocated as a better biomarker of aging than chronological age, and plant-based dietary patterns have been ...
Sicong Wang, Wenyuan Li, Shu Li, Huakang Tu, Junlin Jia, Wenting Zhao, Andi Xu, Wenxin Xu, Min Kuang Tsai, David Ta-Wei Chu, Chi Pang Wen, Xifeng Wu   +11 more
doaj   +1 more source

Alkaline Water and Longevity: A Murine Study [PDF]

, 2016
The biological effect of alkaline water consumption is object of controversy. The present paper presents a 3-year survival study on a population of 150 mice, and the data were analyzed with accelerated failure time (AFT) model.
Baratella, Davide, Bonaiuto, Emanuela, Corain, Livio, Corraducci, Vittorino, Ferro, Silvia, Magro, Massimiliano, Salmaso, Luigi, Terzo, Milo, Vianello, Fabio   +8 more
core   +3 more sources