Results 51 to 60 of about 9,474,361 (376)

Obesity accelerates thymic aging

Blood, 2009
Abstract As the expanding obese population grows older, their successful immunologic aging will be critical to enhancing the health span. Obesity increases risk of infections and cancer, suggesting adverse effects on immune surveillance.
Hyunwon, Yang, Yun-Hee, Youm, Bolormaa, Vandanmagsar, Jennifer, Rood, K Ganesh, Kumar, Andrew A, Butler, Vishwa Deep, Dixit   +6 more
openaire   +3 more sources

Failure of immunosurveillance accelerates aging [PDF]

OncoImmunology, 2019
Immunosurveillance is generally conceived as a mechanism through which the immune system detects and eliminates (pre-)malignant cells, thus reducing the risk of developing cancer. A recent paper by Ovadya et al. demonstrates that knockout of the gene coding for perforin-1 causes accelerated accumulation of senescent cells in multiple mouse organs ...
Maria Perez-Lanzon, Laurence Zitvogel, Guido Kroemer   +2 more
openaire   +4 more sources

Performance Degradation Prediction and Reliability Evaluation of Rubber Aging in Natural Environment Under Alternating Cyclic Thermal Load

IEEE Access, 2019
With a focus on predicting the degradation of rubber performance in the natural environment and evaluating its reliability, the distribution law of accelerated aging life is analyzed through the accelerated aging test of hot oxygen.
Qiaobin Liu, Wenku Shi, Kunhen Li, Zhiyong Chen, Helong Liu   +4 more
doaj   +1 more source

Investigation of Ageing Parameters on Properties of AL/ALBITE MMCs [PDF]

, 2017
The objective of the work was to investigate effect of an accelerated aging on properties of Al6061/albite metal matrix composites(MMCs) such as age hardening, electric resistivity and micro-structural behavior.
Channakeshavalu, P. K. (Prof), M, P. K. (Prof), R, C. P. (Chidanand)   +2 more
core   +1 more source

Subfertility reflects accelerated ovarian ageing [PDF]

Human Reproduction, 2003
The aim of the study was to explore the extent to which accelerated ovarian ageing may lead to subfertility early in reproductive life and eventually cause early menopause.The population studied (n = 2393) never used oral contraceptives, hormone replacement therapy or an intrauterine device.
Kok, Helen S., van Asselt, Kristel M., van der Schouw, Yvonne T., Grobbee, Diederick E., te Velde, Egbert R., Pearson, Peter L., Peeters, Petra H. M.   +6 more
openaire   +3 more sources

Regulation of the mitochondrial transition pore : impact on mammalian aging [PDF]

, 2011
Commentary on: Hafner AV et al. Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging.
Osiewacz, Heinz D.
core   +2 more sources

Accelerated epigenetic aging in newborns with Down syndrome

Aging Cell, 2022
Accelerated aging is a hallmark of Down syndrome (DS), with adults experiencing early‐onset Alzheimer's disease and premature aging of the skin, hair, and immune and endocrine systems.
Keren Xu, Shaobo Li, I. Muskens, N. Elliott, S. Myint, Priyatama Pandey, H. Hansen, L. Morimoto, Alice Y Kang, Xiaomei Ma, C. Metayer, B. Mueller, I. Roberts, K. Walsh, S. Horvath, J. Wiemels, A. D. de Smith   +16 more
semanticscholar   +1 more source

Hybrid Chitosan–TiO₂ Nanocomposite Impregnated in Type A-2186 Maxillofacial Silicone Subjected to Different Accelerated Aging Conditions: An Evaluation of Color Stability

Nanomaterials, 2023
This study explores the impact of the incorporation of a chitosan–TiO2 nanocomposite on the color stability of pigmented room-temperature vulcanization maxillofacial silicone under various accelerated aging conditions.
Faten K. Al-Kadi, Jwan F. Abdulkareem, Bruska A. Azhdar   +2 more
doaj   +1 more source

Accelerated Aging in Cancer Survivors: Cellular Senescence, Frailty, and Possible Opportunities for Interventions

International Journal of Molecular Sciences
The population of cancer survivors has markedly increased due to the rapid improvements in cancer treatment. However, cancer survivors experience accelerated aging, which leads to chronic diseases and other age-related conditions, such as frailty.
Shuo Wang, Najla El Jurdi, Bharat Thyagarajan, A. Prizment, A. Blaes   +4 more
semanticscholar   +1 more source

Melatonin inhibits cytosolic mitochondrial-DNA induced neuroinflammatory signaling in accelerated aging and neurodegeneration.

Journal of Clinical Investigation, 2020
Chronic inflammation is a pathologic feature of neurodegeneration and aging; however, the mechanism regulating this process is not understood. Melatonin, an endogenous free radical scavenger synthesized by neuronal mitochondria, decreases with aging and ...
A. Jauhari, S. Baranov, Y. Suofu, Jinho Kim, Tanisha Singh, S. Yablonska, Fang Li, Xiaomin Wang, Patrick J. Oberly, M. B. Minnigh, S. Poloyac, D. Carlisle, R. Friedlander   +12 more
semanticscholar   +1 more source