Results 81 to 90 of about 9,228,267 (373)

Obesity May Accelerate the Aging Process [PDF]

Frontiers in Endocrinology, 2019
Lines of evidence from several studies have shown that increases in life expectancy are now accompanied by increased disability rate. The expanded lifespan of the aging population imposes a challenge on the continuous increase of chronic disease. The prevalence of overweight and obesity is increasing at an alarming rate in many parts of the world ...
Salvestrini V., Sell C., Lorenzini A.
openaire   +4 more sources

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

Effects of Accelerated Aging and Acid Scarification of Seed Coat with Hydrochloric Acid on Seed Germination Characteristics of Chickpea c.v. Kaka [PDF]

Ikufīziyuluzhī-i Giyāhān-i Zirā̒ī, 2014
To evaluate the effects of accelerated aging and seed coat scarification with Hydrochloric acid (HCl) on seed germination characteristics of chickpea (Cicer arietinum) c.v.
R. Sadrabadi Haghighi
doaj  

Accelerated aging for evaluation of vigor in Brachiaria brizantha ‘Xaraés’ seeds

Journal of Seed Science, 2020
: The aim of this study was to adjust the accelerated aging test to evaluate the physiological potential of seed lots of Brachiaria brizantha ‘Xaraés’, represented by four lots.
Ariadne Morbeck Santos Oliveira, Marcela Carlota Nery, Karina Guimarães Ribeiro, Adriana Souza Rocha, Priscila Torres Cunha   +4 more
doaj   +1 more source

Alkaline Water and Longevity: A Murine Study [PDF]

, 2016
The biological effect of alkaline water consumption is object of controversy. The present paper presents a 3-year survival study on a population of 150 mice, and the data were analyzed with accelerated failure time (AFT) model.
Baratella, Davide, Bonaiuto, Emanuela, Corain, Livio, Corraducci, Vittorino, Ferro, Silvia, Magro, Massimiliano, Salmaso, Luigi, Terzo, Milo, Vianello, Fabio   +8 more
core   +3 more sources

Determinants of accelerated metabolomic and epigenetic aging in a UK cohort

Aging Cell, 2020
Markers of biological aging have potential utility in primary care and public health. We developed a model of age based on untargeted metabolic profiling across multiple platforms, including nuclear magnetic resonance spectroscopy and liquid ...
O. Robinson, Marc Chadeau Hyam, I. Karaman, R. Climaco Pinto, M. Ala-Korpela, E. Handakas, G. Fiorito, He Gao, Andy Heard, M. Jarvelin, M. Lewis, R. Pazoki, S. Polidoro, I. Tzoulaki, M. Wielscher, P. Elliott, P. Vineis   +16 more
semanticscholar   +1 more source

Anxiety disorders and accelerated cellular ageing [PDF]

British Journal of Psychiatry, 2015
BackgroundAnxiety disorders increase the risk of onset of several ageing-related somatic conditions, which might be the consequence of accelerated cellular ageing.AimsTo examine the association between anxiety status and leukocyte telomere length (LTL) as an indicator of cellular ageing.MethodData are from individuals with current (n = 1283) and ...
Verhoeven, J.E., Revesz, D., van Oppen, P.C., Epel, E.S., Wolkowitz, O.M., Penninx, B.W.   +5 more
openaire   +5 more sources

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Factors influencing accelerated aging in patients with type 2 diabetes mellitus and coronary heart disease

Frontiers in Endocrinology
ObjectiveTo investigate the factors influencing accelerated aging in patients with type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD).MethodsA total of 216 patients diagnosed with T2DM and CHD between August 2019 and August 2023 at Xuzhou ...
Zehua Huang, Nana Liu, Shiyi Chen, Zhiren Chen, Peian Wang   +4 more
doaj   +1 more source

Microwave-assisted synthesis of a MK2 inhibitor by Suzuki-Miyaura coupling for study in Werner syndrome cells [PDF]

, 2015
Microwave-assisted Suzuki-Miyaura cross-coupling reactions have been employed towards the synthesis of three different MAPKAPK2 (MK2) inhibitors to study accelerated aging in Werner syndrome (WS) cells, including the cross-coupling of a 2-chloroquinoline
Bagley, Mark C, Baashen, Mohammed, Chuckowree, Irina, Dwyer, Jessica E, Kipling, David, Davis, Terence   +5 more
core   +3 more sources