Results 61 to 70 of about 4,092 (259)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Creep failure characteristics and damage creep model of red layer soft rock based on Perzyna viscoplastic theory

Scientific Reports
Rock creep is essentially a process of damage accumulation. According to the damage evolution of rock under creep conditions, the TAW2000 triaxial test system is used to carry out triaxial creep test on red layer soft rock taken from Yibo Tunnel in ...
Lei Chen, Jinchi Han, Shuguang Zhang, Jiaxu Jin, Baoxin Jia, Jiashun Liu, Jupeng Tang   +6 more
doaj   +1 more source

Research on Unsteady Burgers Creep Constitutive Model and Secondary Development Application

Applied Sciences
Considering the complexity and diversity of water-rich soft soil strata, indoor triaxial shear tests and creep tests were conducted on soft soil to explore its deformation law and creep characteristics.
Ruonan Zhu, Bo Wu, Shixiang Xu, Xi Liu, Heshan Li   +4 more
doaj   +1 more source

Creep Mechanics of the High-Stress Soft Rock under Grade Unloading

Advances in Civil Engineering, 2020
In order to study the creep behavior of deep soft rock, gritstone was chosen as the research subject, and a rock triaxial rheometer (Rock 600-50) and acoustic emission (AE) system (SH-II) were used to carry out the grade unloading confining pressure ...
Shunjie Huang, Xiangrui Meng, Guangming Zhao, Yingming Li, Gang Liu, Chunliang Dong, Xiang Cheng, Wensong Xu, Chongyan Liu, Jun Zhou   +9 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

A new swelling - creep model for red-bed mudstone and its application

Frontiers in Earth Science
In the red-bed region, engineering structures often encounter safety risks due to the swelling and creep properties of mudstone. Presently, there is a deficiency in constitutive equations capable of characterizing mudstone behavior under combined stress ...
Hongyi Yan, Feng Yu, Chaobo Zhu, Jianwei Yuan, Qiang Wang, Jiang Wu   +5 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source