Results 71 to 80 of about 45,082 (299)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Performance and Life Assessment of Reformer Tubes in Petrochemical Industries

High Temperature Materials and Processes, 2014
High temperature mechanical properties of service exposed reformer tubes are compared and revalidated with those of virgin material for the sake of health assessment studies.
Raj A., Goswami B., Kumar S.B., Krishna G., Roy N., Ray A.K.   +5 more
doaj   +1 more source

Modeling afterslip and aftershocks following the 1992 Landers earthquake [PDF]

, 2007
One way to probe the rheology of the lithosphere and fault zones is to analyze the temporal evolution of deformation following a large earthquake. In such a case, the lithosphere responds to a known stress change that can be assessed from earthquake slip
Amelung, Amitrano, Blanpied, Bock, Bodin, Bosl, Bouchez, Chester, Cocks, Cruden, Deng, Dieterich, Dieterich, Dragert, Fialko, Fialko, Goldberg, Gordon, Gross, H. Perfettini, Hardebeck, Hardebeck, Hauksson, Hearn, Hsu, Hsu, Hudnut, J.-P. Avouac, Johnson, King, Lachenbruch, Langbein, Lapusta, Liu, Lockner, Marone, Marone, Massonnet, Miyazaki, Montési, Nelder, Okada, Peltzer, Peltzer, Perfettini, Perfettini, Perfettini, Perfettini, Perfettini, Pollitz, Pollitz, Pollitz, Press, Rice, Rice, Rubin, Rubin, Ruina, Sauber, Sauber, Savage, Savage, Savage, Savage, Scholz, Scholz, Shen, Smith, Stein, Wessel, Zweck   +70 more
core   +3 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Creep damage constitutive model of rock based on the mechanisms of crack-initiated damage and extended damage

Underground Space
Since the classical element model cannot describe the nonlinear characteristics of rock during the entire compressive creep process, nonlinear elements and creep damage are generally introduced in the model to resolve this issue.
Tianbin Li, Chao Chen, Feng Peng, Chunchi Ma, Mou Li, Yixiang Wang   +5 more
doaj   +1 more source

A bistable morphing composite using viscoelastically generated prestress [PDF]

, 2015
Elastically generated prestress within polymeric composites can be used to create bistable morphing structures; i.e. they can ‘snap through’ between one of two states.
Fancey, Kevin S., Wang, Bing
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Non-metallic brush seals for gas turbine bearings [PDF]

, 2004
A non-metallic brush seal has been developed as an oil seal for use in turbomachinary. Traditionally labyrinth-type seals with larger clearances have been used in such applications. Labyrinth seals have higher leakage rates and can undergo excessive wear
Akşit, Mahmut Faruk, Bhate, Nitin, Demiroğlu, Mehmet, Kizil, Huseyin, Thermos, Anthony C.   +4 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source