Results 91 to 100 of about 4,908,366 (272)

Micelle-Cross-Linked Hydrogels with Strain Stiffening Properties Regulated by Intramicellar Cross-Linking

Micelle-cross-linked hydrogels are promising candidates for tough hydrogels with a tailorable chemical composition, nanostructure, mechanical properties, and functionality.
Meng Huo (3161172), Zizhuo Zhao (9088349), Guangjie Song (5522210), Linlin Fan (603135)   +3 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Two-year topographic and densitometric outcomes of accelerated (45 mW/cm2) transepithelial corneal cross-linking for keratoconus: a case-control study

BMC Ophthalmology, 2018
Background Conventional corneal cross-linking is effective for retarding the progression of keratoconus. However the long-term efficacy and safety of accelerated (45 mW/cm2) transepithelial corneal cross-linking (ATE-CXL) on progressive keratoconus (KC ...
Jinrong Huang, Yang Shen, Weijun Jian, Haipeng Xu, Meiyan Li, Jing Zhao, Xingtao Zhou, Hongfei Liao   +7 more
doaj   +1 more source

Controllable Self-Assembly of Amphiphilic Tadpole-Shaped Polymer Single-Chain Nanoparticles Prepared through Intrachain Photo-cross-linking

, 2019
We report the use of intramolecular cross-linking chemistry as a tool to control the self-assembly of amphiphilic diblock copolymers (di-BCPs). Two amphiphilic di-BCPs of poly­(N,N′-dimethylacrylamide)-block-polystyrene (PDMA-b-PS) with photo-cross ...
Jie He (132999), Srinivas Thanneeru (1565047), Weikun Li (1565053)   +2 more
core   +1 more source

High‐Performance Polymeric Materials through Hydrogen‐Bond Cross‐Linking

, 2020
It has always been critical to develop high‐performance polymeric materials with exceptional mechanical strength and toughness, thermal stability, and even healable properties for meeting performance requirements in industry.
Pingan Song, Hao Wang, Song, Pingan, Wang, Hao   +3 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Treatment of Keratoconus Using Accelerated Corneal Cross-Linking [PDF]

, 2019
Summary: Treatment of keratoconus using Accelerated Corneal Cross-Linking Aim: This study evaluates the efficacy of treatment of progressive keratoconus using Accelerated Corneal Cross-linking (ACXL) method.
Veliká, Věra
core  

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Transepithelial Accelerated Corneal Collagen Cross-Linking: Two-Year Results

Clinical Ophthalmology, 2020
Ana Maria Cunha,1 Tiago Sardinha,2 Luís Torrão,1 Raúl Moreira,1 Fernando Falcão-Reis,1,3 João Pinheiro-Costa1,4 1Department of Ophthalmology, Centro Hospitalar De São João, Porto, Portugal; 2Faculty of ...
Cunha AM, Sardinha T, Torrão L, Moreira R, Falcão-Reis F, Pinheiro-Costa J   +5 more
doaj