Results 51 to 60 of about 265,739 (284)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Accelerated collagen cross-linking in the management of advanced Acanthamoeba keratitis [PDF]

Arquivos Brasileiros de Oftalmologia, 2019
To report our initial experience in the treatment of Acanthamoeba keratitis with accelerated corneal collagen cross-linking.Retrospective chart review of patients diagnosed with Acanthamoeba keratitis with progressive corneal melting who were treated with accelerated collagen cross-linking.A total of 6 eyes (5 patients) were reviewed.
Cristian,Cartes, Marco,Casas del Valle, Arturo,Kantor, Claudio,Pérez, Miguel,Srur, Rolf,Raimann, Remigio,López, Leonidas,Traipe   +7 more
openaire   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Protocol for a systematic review, meta-analysis, and trial sequential analysis of clinical outcomes following accelerated versus conventional corneal collagen cross-linking for corneal ectasia

Systematic Reviews, 2019
Background Collagen cross-linking (CXL) is an evolving procedure that enhances the biomechanical rigidity of the cornea and can slow or halt ectatic disease.
Siddharth Nath, Carl Shen, Alex Koziarz, Laura Banfield   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The stability of supported liquid membranes [PDF]

, 1990
In this paper a new hypothesis about the instability mechanism of SLMs will be discussed: emulsion formation induced by lateral shear forces. Experimental results show that a water phase with a low salt concentration which flows along the membrane ...
Bargeman, D., Bargeman, D., Neplenbroek, A.M., Neplenbroek, A.M., Smolders, C.A., Smolders, C.A.   +5 more
core   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Accelerated and Standard Corneal Cross-Linking Protocols in Patients with Down Syndrome: A Non-inferiority Contralateral Randomized Trial

Ophthalmology and Therapy, 2020
Introduction To compare the results of an accelerated corneal cross-linking (CXL) protocol (9 mW/cm2, 10 min) with the standard CXL protocol (3 mW/cm2, 30 min) in patients with Down syndrome (DS) who have keratoconus (KC).
Hassan Hashemi, Kazem Amanzadeh, Mohammad Seyedian, Hojjat Zeraati, Cynthia J. Roberts, Shiva Mehravaran, Renato Ambrósio, Riccardo Vinciguerra, Paolo Vinciguerra, Soheila Asgari   +9 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The effects of berry juice on cognitive decline in older adults : a thesis presented in partial fulfilment of the requirements of Master of Arts in Psychology at Massey University, Palmerston North, New Zealand [PDF]

, 2005
This study examined the effects of blackcurrant and boysenberry juices on cognitive processes in older adults. Current research suggests that fruits such as these may be able to reverse some of the effects of ageing on cognition.
Holdaway, Melanie Anne
core