Results 51 to 60 of about 519,139 (282)

Rank-based inference for the accelerated failure time model in the presence of interval censored data [PDF]

, 2016
Semiparametric analysis and rank-based inference for the accelerated failure time model are complicated in the presence of interval censored data. The main difficulty with the existing rank-based methods is that they involve estimating functions with the
Abu Bakar, Mohd Rizam, Arasan, Jayanthi, Ibrahim, Noor Akma, Karimi, Mostafa   +3 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Instrumental variable estimation for duration data [PDF]

, 2002
In this article we focus on time-to-event studies with a randomised treatment assignment that may be compromised by selective compliance. Contrary to most of the extensive literature on evaluation studies we do not consider the effect of the treatment on
Bijwaard, G.E. (Govert)
core   +4 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The Missing Indicator Approach for Accelerated Failure Time Model with Covariates Subject to Limits of Detection

Stats, 2022
The limit of detection (LOD) is commonly encountered in observational studies when one or more covariate values fall outside the measuring ranges. Although the complete-case (CC) approach is widely employed in the presence of missing values, it could ...
Norah Alyabs, Sy Han Chiou
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

A Generalized Accelerated Failure Time Model to Predict Restoration Time from Power Outages

International Journal of Disaster Risk Science
Major disasters such as wildfire, tornado, hurricane, tropical storm, and flooding cause disruptions in infrastructure systems such as power and water supply, wastewater management, telecommunication, and transportation facilities.
Tasnuba Binte Jamal, Samiul Hasan
doaj   +1 more source

Parametric versus Nonparametric Treatment of Unobserved Heterogeneity in Multivariate Failure Times [PDF]

, 1997
Two contrary methods for the estimation of a frailty model of multivariate failure times are presented. The assumed Accelerated Failure Time Model includes censored data, observed covariates and unobserved heterogeneity.
Hamerle, Alfred, Hornsteiner, U., Michels, P.   +2 more
core   +1 more source

Survival Regression with Accelerated Failure Time Model in XGBoost

Journal of Computational and Graphical Statistics, 2022
Survival regression is used to estimate the relation between time-to-event and feature variables, and is important in application domains such as medicine, marketing, risk management and sales management. Nonlinear tree based machine learning algorithms as implemented in libraries such as XGBoost, scikit-learn, LightGBM, and CatBoost are often more ...
Barnwal, Avinash, Cho, Hyunsu, Hocking, Toby Dylan   +2 more
openaire   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source