Results 91 to 100 of about 395,934 (297)

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

open access: yesMolecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh   +5 more
wiley   +1 more source

Multi-axis Response of a Thermal Convection-based Accelerometer

open access: yesMicromachines, 2018
A thermal convection-based accelerometer was fabricated, and its characteristics were analyzed in this study. To understand the thermal convection of the accelerometer, the Grashof and Prandtl number equations were analyzed.
Jae Keon Kim   +4 more
doaj   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

open access: yesMolecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha   +10 more
wiley   +1 more source

Taxonomy of Vectorization Patterns of Programming for FIR Image Filters Using Kernel Subsampling and New One

open access: yesApplied Sciences, 2018
This study examines vectorized programming for finite impulse response image filtering. Finite impulse response image filtering occupies a fundamental place in image processing, and has several approximated acceleration algorithms.
Yoshihiro Maeda   +2 more
doaj   +1 more source

The Inflation Accelerator

open access: yesSSRN Electronic Journal
We develop a tractable sticky price model in which the fraction of price changesevolves endogenously over time and, consistent with the evidence, increases with inflation. Because we assume that firms sell multiple products and choose how many, but not which, prices to adjust in any given period, our model admits exact aggregation and reduces to a one ...
Blanco, Andrés   +3 more
openaire   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Acceleration of the Extreme Sea Level Rise Along the Chinese Coast

open access: yesEarth and Space Science, 2019
Using high‐frequency tide gauge observations from 1980 to 2017, we analyzed changes in extreme sea levels (ESLs) along the Chinese coast to examine whether extreme sea‐level rise acceleration could be observed.
Jianlong Feng   +5 more
doaj   +1 more source

Accelerating Structures [PDF]

open access: yesarXiv: Accelerator Physics, 2017
CERN Yellow Reports: School Proceedings, Vol 1 (2017): Proceedings of the CAS-CERN Accelerator School on Accelerators for Medical ...
openaire   +3 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Accelerated Motions of a Fish-Like Foil from Impulsive Starts to Terminal States

open access: yesJournal of Fluid Science and Technology, 2012
It is presented through numerical analysis that accelerated motions of a two-dimensional fish-like foil by fluid forces can be modeled from impulsive starts to terminal states.
Youichi OGATA, Tsuyoshi OGASAWARA
doaj   +1 more source

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