Results 61 to 70 of about 1,501,755 (279)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Muon Acceleration in Cosmic-ray Sources

, 2012
Many models of ultra-high energy cosmic-ray production involve acceleration in linear accelerators located in Gamma-Ray Bursts magnetars, or other sources.
Antchev, Arons, Becker, Bell, Bell, Dzhilkibaev, Fang, Fermi, Gaisser, He, Julia Becker Tjus, Koers, Mannheim, Murase, Rune E. Mikkelsen, Spencer R. Klein, Tajima, Waxman, Waxman, Waxman, Waxman, Zhang   +21 more
core   +1 more source

Methylation age acceleration does not predict mortality in schizophrenia. [PDF]

, 2019
Schizophrenia (SCZ) is associated with high mortality. DNA methylation levels vary over the life course, and pre-selected combinations of methylation array probes can be used to estimate "methylation age" (mAge). mAge correlates highly with chronological
Burrage, Joe, Hannon, Eilis, Kowalec, Kaarina, Mansell, Georgina, Mill, Jonathan, Ophoff, Roel A, Ori, Anil PS, Sullivan, Patrick F   +7 more
core   +1 more source

Calculation of Driving Parameters for GOA4 Signaling System using Machine Learning Methods

Sakarya University Journal of Computer and Information Sciences, 2022
Among the electromechanical components of the rail system, the rail system vehicle is one of the most important units that carrying the passenger load.
Mehmet Taciddin Akçay, Abdurrahim Akgundogdu   +1 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Observation of 99Mo radioactivity produced in natural molybdenum irradiated with an electron beam from a linear industrial accelerator

Nukleonika
The authors present the first observation of the production of 99Mo using a direct electron beam obtained from an electron linear accelerator in the 10–20 MeV energy region.
Zawistowski Tobiasz, Wronka Sławomir, Adrich Przemysław, Chabera Mariusz, Cieszykowska Izabela, Janiak Tomasz, Kosiński Tymoteusz, Matusiak Michał   +7 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Simulations of Ion Acceleration at Non-relativistic Shocks. I. Acceleration Efficiency

, 2014
We use 2D and 3D hybrid (kinetic ions - fluid electrons) simulations to investigate particle acceleration and magnetic field amplification at non-relativistic astrophysical shocks.
Caprioli, Damiano, Spitkovsky, Anatoly
core   +1 more source

Reverse spin bias: preliminary observations of reporting bias in medical systematic reviews

Research Integrity and Peer Review
Background While conducting an umbrella review of e-cigarettes for smoking cessation, we observed that in many instances, systematic review authors reported findings favorable to the treatment, yet they declined to recommend it or recommended against it ...
Renée O’Leary, Giusy Rita Maria La Rosa, Riccardo Polosa   +2 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source