Results 51 to 60 of about 5,548,205 (246)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Shaking table tests on topographic effects of circular-arc valleys

Yantu gongcheng xuebao
As a typical locally irregular topography, the valley can change the seismic properties within the local site, which is usually called the topographic effects.
ZHANG Zhongjie 1, YU Haitao 2, SONG Yi 3, LIU Shu 1, WANG Zhikun 3
doaj   +1 more source

High-Resolution Permanent Magnet Drive Using Separated Observers for Acceleration Estimation and Control

Sensors, 2022
This paper proposes a high-resolution permanent magnet (PM) motor drive based on acceleration estimation and control. The PM motor is widely implemented in the printed circuit board (PCB) manufacturing process.
Yi-Jen Lin, Po-Huan Chou, Shih-Chin Yang
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Increased rate of acceleration on Pine Island Glacier strongly coupled to changes in gravitational driving stress [PDF]

, 2009
Pine Island Glacier, Antarctica, has been undergoing several related changes for at least two decades; these include acceleration, thinning and grounding line retreat.
Scott, J. B. T., Vaughan, D G, Bingham, R. G., R. G. Bingham, Pritchard, H.D., Vaughan, D. G., Bingham, R.G., Pritchard, Hamish D., Scott, J.B.T., Smith, A. M., Vaughan, D.G., Pritchard, H. D., J. B. T. Scott, Gudmundsson, G H, Smith, A M, Pritchard, H D, Smith, A.M., Gudmundsson, G.H., D. G. Vaughan, Vaughan, David G., G. H. Gudmundsson, Scott, J B T, H. D. Pritchard, Bingham, R G, Gudmundsson, G. H., Gudmundsson, Hilmar, A. M. Smith, Bingham, Robert G.   +27 more
core   +2 more sources

Dynamic measurements to assess stress levels on buried hydraulic structures

Water Science
Old masonry structures have a very special nature that require periodical inspection and evaluation programs. The problem becomes more sophisticated when dealing with vital buried hydraulic structures under continuous functional operation while bearing ...
A. M. Anwar, A. S. Hashad, M. Omar
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

An Experiment Monitoring Signals of Coal Bed Simulation under Forced Vibration Conditions

Shock and Vibration, 2015
An experiment simulating coal seam under forced vibration conditions was conducted. Acceleration response and microseism signal during the experiment were collected and analyzed.
Chengwu Li, Po Hu, Tianbao Gao, Yingfeng Sun, Shengyang Shao, Qifei Wang   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source