Results 61 to 70 of about 199,344 (312)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Effects of Underground Structure on Acceleration Response of Site

open access: yes, 2011
Through numerical simulation,the article analyzes the difference of ground surface acceleration response under the condition of free site and underground structure.
Chao Sun, Qing Wang
core   +1 more source

Disturbance estimation for RUAV using UKF with acceleration measurement

open access: yes, 2015
Rotorcraft unmanned aerial vehicles (RUAV) have been widely used in many fields. However, one of the bottleneck problems of RUAV control is how to ensure its motion steady under huge external disturbances such as wind.
He YQ(何玉庆)   +2 more
core   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Host immune responses accelerate pathogen evolution [PDF]

open access: yesThe ISME Journal, 2013
Abstract Pathogens face a hostile and often novel environment when infecting a new host, and adaptation is likely to be an important determinant of the success in colonization and establishment. We hypothesized that resistant hosts will impose stronger selection on pathogens than susceptible hosts, which should accelerate pathogen ...
Trivedi, Pankaj (R17491), Wang, Nian
openaire   +3 more sources

Reliability Study of Spectral Acceleration Designs Against Earthquakes in Bengkulu City, Indonesia

open access: yesInternational Journal of Technology, 2018
This paper presents a reliability study of spectral acceleration designs against earthquakes in Bengkulu City. Seismic Hazard Analysis of 1,968 events is performed to define the controlling earthquake event.
Lindung Zalbuin Mase
doaj   +1 more source

The response of the vestibulosympathetic reflex to linear acceleration in the rat [PDF]

open access: yesJournal of Neurophysiology, 2016
The vestibulosympathetic reflex (VSR) increases blood pressure (BP) upon arising to maintain blood flow to the brain. The optimal directions of VSR activation and whether changes in heart rate (HR) are associated with changes in BP are still not clear.
S B, Yakushin   +3 more
openaire   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Apparent mass of small children: Experimental measurements

open access: yes, 2004
A test facility and protocol were developed for measuring the seated, vertical, whole-body vibration response of small children of less than 18 kg in mass over the frequency range from 1 to 45 Hz.
Giacomin, J
core   +1 more source

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