Results 71 to 80 of about 2,234,030 (304)

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Measurement of correlated charge noise in superconducting qubits at an underground facility

Nature Communications
The charge environment of superconducting qubits may be studied through the introduction of controlled, quantified amounts of ionizing radiation. We measure space- and time-correlated charge jumps on a four-qubit device, operating 107 meters below the ...
G. Bratrud, S. Lewis, K. Anyang, A. Colón Cesaní, T. Dyson, H. Magoon, D. Sabhari, G. Spahn, G. Wagner, R. Gualtieri, N. A. Kurinsky, R. Linehan, R. McDermott, S. Sussman, D. J. Temples, S. Uemura, C. Bathurst, G. Cancelo, R. Chen, A. Chou, I. Hernandez, M. Hollister, L. Hsu, C. James, K. Kennard, R. Khatiwada, P. Lukens, V. Novati, N. Raha, S. Ray, R. Ren, A. Rodriguez, B. Schmidt, K. Stifter, J. Yu, D. Baxter, E. Figueroa-Feliciano, D. Bowring   +37 more
doaj   +1 more source

Shell-driven mode evolution in the fission of sub-lead nuclei [PDF]

EPJ Web of Conferences
Systematic measurements and analysis of the heavy-ion fusion-fission of 148,152,154,158Dy, 160,164,168 Yb, and 176,178,180,184,186Pt isotopes are presented, spanning a wide range of neutron-to-proton ratios in the sub-lead region.
Muddam V. S., Buete J., Cook K. J., Hinde D. J., Dasgupta M., Hayles S. L., Lee H., Seabra C. C., Stuchbery J. A., Tran T., Webber M. M.   +10 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Velocity dispersion of correlated energy spread electron beams in the free electron laser

New Journal of Physics, 2017
The effects of a correlated linear energy/velocity chirp in the electron beam in the free electron laser (FEL), and how to compensate for its effects by using an appropriate taper (or reverse-taper) of the undulator magnetic field, is well known.
L T Campbell, A R Maier
doaj   +1 more source

Accelerator physics at LEP [PDF]

Reports on Progress in Physics, 2000
Accelerator physics issues and their influence on performance are presented for the Large Electron-Positron (LEP) storage ring at CERN in Geneva, Switzerland. After several years of operation on the Z boson resonance at beam energies around 45 GeV, the beam energy was increased in steps to over 100 GeV. The major power loss to synchrotron radiation and
D Brandt, H Burkhardt, M Lamont, S Myers, J Wenninger   +4 more
openaire   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Conceptual design of a nonscaling fixed field alternating gradient accelerator for protons and carbon ions for charged particle therapy [PDF]

, 2013
The conceptual design for a nonscaling fixed field alternating gradient accelerator suitable for charged particle therapy (the use of protons and other light ions to treat some forms of cancer) is ...
Wilson P, J. Strachan, J. H. Cobb, P. A. McIntosh, Edgecock TR, Witte, H., Cobb, JH, Tygier S, Edgecock, T. R., Rochford J, P. Wilson, Easton, MJ, Sheehy, SL, Owen HL, Smith, SL, J. Rochford, Machida, S., Wilson, P., Strachan, J, Prior, C.R., Vojnovic, B, Witte H, R. Fenning, Owen, H.L., Barlow, R. J., Vojnovic, B., J. Pasternak, R. Seviour, Pattalwar, S., S. Tygier, Barlow RJ, Jones, B., Machida, S, Cobb JH, Yokoi, T., Beard, CD, Edgecock, TR, Gardner, I.S.K., N. Bliss, Pattalwar, S, Kelliher, DJ, C. D. Beard, I. S. K. Gardner, Fenning, R., Fenning R, B. Vojnovic, McIntosh, P.A., Strachan J, T. R. Edgecock, A. Khan, Seviour, R., Jones B, Cobb, J. H., Aslaninejad M, Prior, CR, Owen, HL, Hill, M. A., Smith, S. L., Pozimski J, Peach, K.J., Peach, K. J., Seviour R, M. J. Easton, Rochford, J, Seviour, R, Easton, M. J., Beard, C. D., Gardner, I. S. K., Prior, C. R., B. Jones, Beard, C.D., Seviour, Rebecca, Strachan, J., Gardner ISK, Smith SL, Cobb, J.H., Jones, T., Easton, M.J., Aslaninejad, M, Pasternak, J., S. L. Sheehy, Jones, T, C. R. Prior, Kelliher, D. J., D. J. Kelliher, Wilson, P, Yokoi, T, Yokoi T, McIntosh PA, Rogers CT, Rogers, C.T., M. A. Hill, S. L. Smith, Pasternak, J, Vojnovic, Boris, Hill MA, S. Machida, Pozimski, J, Johnstone, CJ, Owen, H. L., R. J. Barlow, Gardner, ISK, C. J. Johnstone, Beard CD, H. L. Owen, H. Witte, Gardner, I. S.K., Jones, B, Hill, M.A., Witte, H, J. Pozimski, Rochford, J., Machida S, Jones T, T. Yokoi, Khan, A., Prior CR, Pattalwar S, Bliss, N., Johnstone CJ, Tygier, S., McIntosh, PA, Rogers, C. T., Edgecock, R., Kelliher, D.J., Peach KJ, Pozimski, J., Khan, A, Barlow, R.J., M. Aslaninejad, Johnstone, C.J., Sheehy SL, Vojnovic B, C. T. Rogers, Tygier, S, Johnstone, C. J., McIntosh, P. A., Kelliher DJ, Barlow, RJ, S. Pattalwar, Sheehy, S. L., Pasternak J, Aslaninejad, M., Bliss N, Khan A, Easton MJ, T. Jones, Rogers, CT, K. J. Peach, Fenning, R, Gardner, I. S K, Hill, MA, Smith, S.L., Bliss, N   +153 more
core   +1 more source

Zeptosecond dynamics of superheavy element synthesis reactions: The role of sequential fission [PDF]

EPJ Web of Conferences
Our understanding of quasifission and thus superheavy element formation may be hindered by sequential fission, a secondary process that results in three final quasifission fragments rather than the expected two.
Hayles S.L., Buete J., Cook K.J., Hinde D.J., Dasgupta M., Bezzina L.T., Haba H., Lakelin M.K., Lee H., Seabra C.C., Tran T., Webber M.M.   +11 more
doaj   +1 more source