Results 91 to 100 of about 58,510 (335)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
On shortening, lengthening, and accent shifts in Slavic
Rasprave Instituta za Hrvatski Jezik i Jezikoslovlje, 2017 The paper deals with several problems of Slavic historical accentology – pretonic length in the accentual paradigm c (and b) in South and West Slavic, the neo-circumflex phenomenon (including the accent in the genitive plural), the kȍkōt ‘rooster’ type ...
Mate Kapović
doaj
ACCENTUATION OF VERBAL SUFFIXAL NOUNS WITH FLEXIONS -А, -Я
, 2021 A. A. Zyniakova
openalex +1 more source
Indo-Uralic consonant gradation [PDF]
, 2010 Koivulehto and Vennemann have recently (1996) revived Posti’s theory (1953) which attributed Finnic consonant gradation to Germanic influence, in particular to the influence of Verner’s law. This theory disregards the major differences between Finnic and
Kortlandt, Frederik H. H.
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Miscellaneous remarks on Balto-Slavic accentuation [PDF]
, 2010 The highly successful conference on Balto-Slavic accentology organized by Mate Kapovic and Ranko Matasovic has given much food for thought. It has clarified the extent of fundamental disagreements as well as established areas of common interest where the
Kortlandt, Frederik H. H.
core
Samuel Zyman’s "Concerto for Cello and Orchestra": An Analytical Approach [PDF]
, 2020 A professor at The Juilliard School since 1986, Zyman is one of Mexico’s foremost composers of today. His cello concerto (1990) exhibits solid technique, intense expression, and effective interaction between soloist and orchestra. The author demonstrates
Barrón Corvera, Jorge
core
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source