Results 71 to 80 of about 1,492,720 (294)

Respiratory Syncytial Virus infection: New prevention strategies

Global Pediatrics
Respiratory Syncytial Virus is the most common respiratory pathogen in infants and young children. Despite its global impact on human health, no effective treatment is available except for supportive therapy. In the last two decades, our understanding of
Anna Chiara Vittucci, Livia Antilici, Andrea Dotta, Renato Cutrera, Alberto Villani   +4 more
doaj   +1 more source

Extended Technology Acceptance Model for SPSS Acceptance among Slovenian Students of Social Sciences

Organizacija, 2014
Background and Purpose - IBM SPSS Statistics is among the most widely used programs for statistical analysis in social sciences. Due to many practical values it is frequently used as a tool for teaching statistical concepts in many social science ...
Brezavšček Alenka, Šparl Petra, Žnidaršič Anja   +2 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The effectiveness of an acceptance and commitment therapy self-help intervention for chronic pain [PDF]

, 2010
Objective: To evaluate the effectiveness of an Acceptance Commitment Therapy based self-help book for people with chronic pain. Method: This was a randomized 2 group study design.
Shennan, Jeannette, Johnston, Marnie Ruth, Starkey, Nicola J., Foster, T. Mary, Johnson, Anders, Nicola J. Starkey, Jeannette Shennan, Prof Mary Foster, Marnie Johnston, Nicola J, Anders Johnson, Mary Foster, Starkey Phda, M. D. Phdb, Msocsci/pgdip Clin Psychb, Msocsci/pgdip Clin Psycha   +15 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Dangers to be avoided in trade acceptance practice,

, 1919
An address before the convention of the American acceptance council at Detroit, June 9, 1919.Reprint.Mode of access ...
Wills, David C., American Acceptance Council.   +1 more
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source