Results 81 to 90 of about 1,492,720 (294)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Integration of Acceptability Analyses into an Adaptive Landscape Co-Design and Management Approach—The Acceptability and Landscape Design Cycle (ALDC)

Land
Acceptability analyses of place–based innovations provide crucial in-depth knowledge (e.g., perceptions and values on landscapes) for the social–ecological transformation of landscapes. However, previous acceptability analyses often neglected complex and
Maria Busse, Jana Zscheischler, Nico Heitepriem, Rosemarie Siebert   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Promoting Peer Interaction and Acceptance Among Students with Special Needs Through an Experiential Learning Program

Children
Background/Objectives: Inclusive education emphasizes positive interactions between students with and without special needs to foster mutual understanding and acceptance.
Hsiu-Ming Lin, Szu-Yin Chu, Wen-Hsuan Chang, I-Hsuan Lo, Hsin-Ting Peng   +4 more
doaj   +1 more source

Acceptance of Tinnitus: Validation of the Tinnitus Acceptance Questionnaire

Cognitive Behaviour Therapy, 2013
The concept of acceptance has recently received growing attention within tinnitus research due to the fact that tinnitus acceptance is one of the major targets of psychotherapeutic treatments. Accordingly, acceptance-based treatments will most likely be increasingly offered to tinnitus patients and assessments of acceptance-related behaviours will thus
Weise, Cornelia, Kleinstäuber, Maria, Hesser, Hugo, Westin, Vendela Zetterqvist, Andersson, Gerhard   +4 more
openaire   +5 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Acceptance and hesitancy towards COVID-19 vaccines in rural and tribal areas of Maharashtra (India)

Journal of Infection in Developing Countries
Introduction: Hesitancy towards COVID-19 vaccines may be a major hindrance to a successful vaccination program. We assessed the vaccine uptake, facilitators, and barriers for the COVID-19 vaccine in tribal and rural populations in Maharashtra, India ...
Maninder Singh Setia, Ashlesha Tawde, Nisha Relwani, Prasad Waingankar, Revathi Natesan, Vijay Kamale, Bageshree Seth   +6 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The Role of Critical Consciousness and Parental Acceptance in LGBTQ+ Youth Mental Health

Social Sciences
Research shows that parental acceptance can serve as a protective factor against negative mental health outcomes among LGBTQ+ youth. Although a few studies have examined the role of critical consciousness in mental health outcomes among LGBTQ+ youth ...
Teresa Vazquez, Rodrigo Costa, Roberto L. Abreu   +2 more
doaj   +1 more source