Results 91 to 100 of about 1,616,125 (301)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Components of arithmetic theory acceptance

open access: yesSynthese
AbstractThis paper ties together three threads of discussion about the following question: in accepting a system of axioms , what else are we thereby warranted in accepting, on the basis of accepting ? First, certain foundational positions in the philosophy of mathematics are said to be epistemically stable, in that there exists a coherent rationale ...
openaire   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Austrian Economics and Game Theory a Preliminary Methodological Stocktaking [PDF]

open access: yes
This paper discusses, from the perspective of Austrian economics, the merits and drawbacks of game theory in economics. It begins by arguing that Austrians have neglected game theory at their peril, and then argues that game theoretic reasoning may be ...
Nicolai J. Foss
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Design of Fuzzy Sampling Plan Using the Birnbaum-Saunders Distribution

open access: yesMathematics, 2018
Acceptance sampling is one of the essential areas of quality control. In a conventional environment, probability theory is used to study acceptance sampling plans.
Muhammad Zahir Khan   +3 more
doaj   +1 more source

Feasibility Study Of Lecturers’ Acceptance Of E-Assessment [PDF]

open access: yes, 2014
Technology acceptance studies are an effective way of gauging future system use and developing a robust system. In the area of e-learning numerous technology acceptance studies exist.
Imtiaz, Md. Athar, Maarop, Nurazean
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Key factors influencing intention to use ChatGPT: An empirical study of U.S. students

open access: yesActa Psychologica
ChatGPT, a generative AI chatbot, has seen unprecedented adoption, yet the factors driving its acceptance among students remain underexplored. This study investigates key determinants of U.S.
Long Pham, Tim Klaus, Justin Bateh
doaj   +1 more source

Epistemic Pluralism [PDF]

open access: yes, 2017
The present paper wants to promote epistemic pluralism as an alternative view of non-classical logics. For this purpose, a bilateralist logic of acceptance and rejection is developed in order to make an important di erence between several concepts of ...
Schang, Fabien
core  

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