Gabpα‐Pparγ Complex Determines Glycolytic Capacity and Lactic Acid Homeostasis in Brown Fat
This study identifies the Gabpα–Pparγ complex as a key transcriptional regulator that couples glycolysis to lactate‐driven thermogenesis in brown adipose tissue by directly activating Eno1 transcription. Competitive disruption of this interaction impairs lactate metabolism and thermogenic capacity.
Zhihan Wang +22 more
wiley +1 more source
Induction and Regeneration of Microspore-Derived Embryos for Doubled Haploid Production in Cabbage (Brassica oleracea var. capitata). [PDF]
Choi SB, Mo SY, Park HY.
europepmc +1 more source
Eucalypt initial growth in response to nursery acclimatization.
Jane Luísa Wadas Lopes +3 more
openalex +1 more source
Effects of ocean acidification on marine biodiversity and ecosystem function [PDF]
Barry, JP +2 more
core +1 more source
Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang +13 more
wiley +1 more source
Light spectrum effects on micropropagation and gene expression of <i>Bucephalandra</i> sp. in a temporary immersion system for sustainable production. [PDF]
Laksana C +3 more
europepmc +1 more source
The acclimatization of mice to atmospheres containing low concentrations of carbon monoxide
Esther M. Killick
openalex +2 more sources
A multifunctional nano immunostimulant is first proposed for efficient tumor immunotherapy. The ER targeted ability, superior ROS production, efficient GSH consumption, coupled with the HIF suppression, jointly arouses ICD/ferroptosis pathways to realize efficient tumor immunotherapy.
Guanhong Guo +14 more
wiley +1 more source
DNA methylation in adaptation to high-altitude environments and pathogenesis of related diseases. [PDF]
Zhang X, Yang Y, Shi Q.
europepmc +1 more source

