PEA nanoenzymes are assembled from L‐arginine and EGCG. The nitrogen element in arginine enhances the thermodynamic feasibility of H2O2 production through PEA's oxygen reduction catalysis, enabling nitrogen‐dependent H2O2 release. Intradermal delivery of PEA via microneedles promotes efficient H2O2 synthesis, thereby stimulating regrowth in telogen ...
Yifei Wang +7 more
wiley +1 more source
Quantifying localized heatwave impact on mortality: a multi-country modeling study in the Asia-Pacific region. [PDF]
Tao J +11 more
europepmc +1 more source
Principales méthodes de lutte intégrée contre les mouches des fruits en Afrique de l'Ouest : Fiche n° 6. Projet régional de lutte contre les mouches des fruits en Afrique de l'Ouest [PDF]
Adandonon, Appolinaire +2 more
core
Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang +17 more
wiley +1 more source
Potential impacts of nanoparticles integration on micropropagation efficiency: current achievements and prospects. [PDF]
Guru GR +3 more
europepmc +1 more source
The Development of Cold War Soldiery: Acclimatisation Research and Military Indoctrination in the Canadian Arctic, 1947-1953 [PDF]
Matthew S. Wiseman
core +1 more source
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao +8 more
wiley +1 more source
Editorial: Essence of survival: impact of primary and secondary metabolism on plant acclimation to abiotic stress. [PDF]
Sulieman S, Li W, Tran LP.
europepmc +1 more source
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao +8 more
wiley +1 more source

