Results 71 to 80 of about 90,660 (244)
Advanced Science, EarlyView.New research reveals that oxytocin signaling during the early postnatal period is critical for regulating brain development and social behavior. Selectively suppressing oxytocin neurons by chemogenetic method shows that early—but not late—disruption leads to autism‐like behaviors.
Zi‐Hui Wang +10 more
wiley +1 more source
An Essay on Concept and Essencials of Acclimatization
Anales de la Facultad de Medicina, 2014 On what conditions should acclimatization-theory be established as a science?. In analyzing the concept of acclimatization scientifically, we are several prevailing interpretation of the concept but cannot find an overal established and accepted interpretation of the concept.
openaire +5 more sources
Advanced Science, EarlyView.Aided by FABP5, abnormally elevated asprosin in hepatocytes enters the nucleus, targets and inhibits PPARα binding to the CPT1A promoter, thereby suppressing FAO. Circulating asprosin exacerbates insulin resistance, collectively driving MASLD progression.
Yuan‐Yuan Yu +13 more
wiley +1 more source
Gelsolin's Protective Role in MASH through F‐Actin Regulation and P53 Degradation
Advanced Science, EarlyView.Gelsolin (GSN) maintains liver metabolic homeostasis by promoting MDM2‐mediated P53 degradation and inhibiting F‐actin/Yes‐associated protein (YAP) overactivation. Loss of GSN impairs P53 degradation, increases lipid deposition, and enhances YAP‐driven fibrosis and inflammation in metabolic‐associated steatohepatitis.
Yiwei Lu +9 more
wiley +1 more source
Acclimatization to heat in humans [PDF]
The responses and mechanisms of both natural and artificial acclimatization to a hot environment in mammals are addressed with specific reference to humans.
Greenleaf, John E. +1 more
core +1 more source
Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species
Advanced Science, EarlyView.This study identifies ferroptosis as a key driver of cellular senescence, with its inhibition delaying aging and extending healthspan across species. During senescence, ferroptosis worsens, increasing oxidative stress and lipid peroxidation, which accelerate aging.
Hai‐Jun Fu +15 more
wiley +1 more source
Human acclimation and acclimatization to heat: A compendium of research, 1968-1978 [PDF]
s and annotations of the majority of scientific works that elucidate the mechanisms of short-term acclimation to heat in men and women are presented. The compendium includes material from 1968 through 1977.
Fox, S. C. +3 more
core +1 more source
Advanced Science, EarlyView.This study presents decursin, a traditional Chinese medicine monomer, that inhibits lipid accumulation and inflammation in atherosclerosis through PKCδ interaction. A novel targeted delivery system (ALD@EM) is developed to overcome decursin's short half‐life, combining antibody‐mediated targeting, LDL‐facilitated chemotaxis, and enhanced macrophage ...
Hui Chen +13 more
wiley +1 more source
Advanced Science, EarlyView.SCORT–Cas13d–pre‐gHoxB13 lipid nanoparticles precisely deliver Cas13d mRNA and guide RNAs to metastatic prostate tumors in the liver, knocking down the “undruggable” transcription factor HoxB13. This approach suppresses metastatic tumor growth, extends mouse survival, and does not induce major organ toxicity or immune activation, offering a safe and ...
Zhifen Cui +15 more
wiley +1 more source
Agricultural pest destruction movement in New Zealand [PDF]
, 1978 New Zealand could be regarded as an acclimatization laboratory, i.e., the consequence of a wide range of animal introductions in the period 1840-1907. Species introduced ranged from camels to hedgehogs, ostriches to sky larks. Fortunately, many failed to
Nelson, Peter C.
core