Results 81 to 90 of about 71,406 (306)

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

The retention of cold acclimatization in sheep

, 1974
SUMMARYShorn Blackface sheep were acclimatized to cold by acute or chronic exposures. Acclimatization caused increased resistance to body cooling (IRC) during acute exposure and elevated heart rates at thermoneutrality (28°C).
J. Slee
core   +1 more source

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

Advanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li, Hui Yuan, Honglei Xiao, Xiaodong Liu, Wenguo Cui   +4 more
wiley   +1 more source

Challenges in the Production of High-Quality Seed Potatoes (Solanum tuberosum L.) in the Tropics and Subtropics

Agronomy, 2020
The potato has been a widely used vegetable crop in temperate countries for a long time. Its consumption and the area of its cultivation has increased significantly over the past decades in the tropics and subtropics as well.
Beata Wasilewska-Nascimento, Dominika Boguszewska-Mańkowska, Krystyna Zarzyńska   +2 more
doaj   +1 more source

Making Sweat Measurable: Induction, Sampling, and Refreshment in Wearable Biofluid Sensing

Advanced Science, EarlyView.
Wearable sweat sensing relies not only on chemical detection but also on controlled biofluid management. This Review integrates sweat physiology, induction strategies, and microfluidic sampling architectures, demonstrating how flux, transport, and refreshment shape measurement reliability.
Soyoung Shin, Wei Gao
wiley   +1 more source

A simple and efficient CRISPR/Cas9 platform for induction of single and multiple, heritable mutations in barley (Hordeum vulgare L.)

Plant Methods, 2018
Background Genome editing of monocot plants can be accomplished by using the components of the CRISPR/Cas9 (clustered regularly interspaced short palindromic repeat/CRISPR associated Cas9) technology specifically optimized for these types of plants. Here,
Sebastian Gasparis, Maciej Kała, Mateusz Przyborowski, Leszek A. Łyżnik, Wacław Orczyk, Anna Nadolska-Orczyk   +5 more
doaj   +1 more source

Acclimatization improves submaximal exercise economy at 5533 m [PDF]

, 2011
We tested whether the better subjective exercise tolerance perceived by mountaineers after altitude acclimatization relates to enhanced exercise economy.
M. Maggiorini, Maggiorini, M, Hefti, U, T. M. Merz, Bloch, KE, A. J. Turk, Merz, T M, Pichler Hefti, J, K. E. Bloch, Merz, Tobias Michael, U. Hefti, Schoch, O D, Barthelmes, D, Hess, T, Latshang, T D, Bosch, M M, T. D. Latshang, Turk, A J, Turk, AJ, T. Hess, Bosch, MM, Hefti, J P, Schoch, OD, O. D. Schoch, D. Barthelmes, J. Pichler Hefti, Bloch, K E, Latshang, TD, M. M. Bosch   +28 more
core   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Model summary of varying daily acclimatization rates.

, 2014
Model summary of varying daily acclimatization rates.
Wessel Van Leeuwen (5661058), Göran Kecklund (415786), Stephen Hough (647352), David Karlsson (532342), Torbjörn Åkerstedt (3343088), Michael Ingre (444640), Christer Ullvetter (647351), Tomas Klemets (647350)   +7 more
core   +1 more source

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source