Results 51 to 60 of about 8,549 (303)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Numerical Investigation on the Strain Evolution of Ti-6Al-4V Alloy during Multi-directional Forging at Elevated Temperatures

High Temperature Materials and Processes, 2018
Multi-directional forging (MDF) is one of the most promising severe plastic deformation (SPD) methods used in fabricating large-scale bulk metal materials with ultra-fine grains (UFG). A finite element model for MDF is developed to investigate the strain
Yan Chenkan, Shen Jun, Lin Peng
doaj   +1 more source

Corrosion Behavior of Al-2wt%Cu Alloy Processed By Accumulative Roll Bonding (ARB) Process [PDF]

Journal of Ultrafine Grained and Nanostructured Materials, 2016
Accumulative roll bonding (ARB) imposes severe plastic strain on materials without changing the specimen dimensions. ARB process is mostly appropriate for practical applications because it can be performed readily by the conventional rolling process.
Mohammad Abdolahi Sereshki, Bahram Azad, Ehsan Borhani   +2 more
doaj   +1 more source

Enhanced Mechanical Properties and Microstructure of Accumulative Roll-Bonded Co/Pb Nanocomposite

Nanomaterials, 2021
Lead composites have been used as anodes in the electrowinning process to produce metals such as copper and zinc. Manufacturing stable lead anodes with appropriate mechanical and chemical properties is required to improve the performance of the ...
Maryam Karbasi, Eskandar Keshavarz Alamdari, Elahe Amirkhani Dehkordi, Zulfiqar A. Khan, Fariborz Tavangarian   +4 more
doaj   +1 more source

Evaluation of Accumulated Axial Plastic Strain of Sands under Long-term Cyclic Loading [PDF]

Journal of Ocean Engineering and Technology, 2014
한국해양공학회지 제28권 제2호, pp 133-139, 2014년 4월 / ISSN(print) 1225-0767 / ISSN(online) 2287-6715Received 10 January 2014, revised 14 April 2014, accepted 15 Ap ril 2014Corresponding author Sung-Ryul Kim: +82-51-200-7622, sungryul@d au.ac.kr◯c 2014, The Korean Society of Ocean EngineersOriginal Research Article Journal of Ocean Engineering and Technology 28(2),
Min-Chang Seo, Si-Hoon Lee, Sung-Ryul Kim   +2 more
openaire   +1 more source

Mechanical Behaviour of Pure Aluminum Processed by Constrained Groove Pressing [PDF]

, 2013
Severe Plastic Deformation (SPD) process is capable of developing the submicron grain structures in metallic alloys and to improve the Mechanical properties.
Shantharaja, M.
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Accumulative deformation law and control of compacted lateritic soil under coupled action of wetting and dynamic loading

Yantu gongcheng xuebao
To address the problem that the in-service lateritic soil subgrade is prone to wetting and excessive additional deformation under the combined effects of traffic loading in southern rainy areas of China, the static triaxial tests with different moisture ...
LIU Weizheng 1, 2, HUANG Xuanjia 1, XU Yang 1, LI Huili 3, WAN Jiale 1
doaj   +1 more source

Harnessing Fungal Biowelding for Constructing Mycelium‐Engineered Materials

Advanced Engineering Materials, EarlyView.
Mycelium‐bound composites (MBCs) offer low‐carbon alternatives for construction, yet interfacial bonding remains a critical challenge. This review examines fungal biowelding as a biocompatible adhesive, elucidating mycelium‐mediated interfacial mechanisms and their role in material assembly. Strategies to optimize biowelding are discussed, highlighting
Xue Brenda Bai, Xinrui Sarah Niu, Zhao Qin   +2 more
wiley   +1 more source