Results 41 to 50 of about 1,450 (264)

Formation mechanism of continuous gas leakage paths in cement sheath during hydraulic fracturing

Energy Science & Engineering, 2020
Continuous gas leakage paths of cement sheath during hydraulic fracturing were investigated in this study. The finite‐element models of a casing–cement‐sheath–formation assembly for the whole wellbore were established, the integrity of the cement sheath ...
Wei Lian, Jun Li, Qian Tao, Jinlong Du, Lei Wang, Yan Xi   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Accumulative deformation law and control of compacted lateritic soil under coupled action of wetting and dynamic loading

Yantu gongcheng xuebao
To address the problem that the in-service lateritic soil subgrade is prone to wetting and excessive additional deformation under the combined effects of traffic loading in southern rainy areas of China, the static triaxial tests with different moisture ...
LIU Weizheng 1, 2, HUANG Xuanjia 1, XU Yang 1, LI Huili 3, WAN Jiale 1
doaj   +1 more source

The Suitability of Using Accumulated Plastic Strain to Assess the Damage at the Rail-Wheel Interfaces [PDF]

Civil-Comp Proceedings, 2012
Numerous Abaqus [1] finite element analyses have been carried out using various plasticity models to investigate the effect of friction force on the rail head in relation to both the development of the accumulated plastic strain (PEEQ) and the changes in the depth of PEEQ distribution in the wheel-rail contact. The normal force distribution on the rail
Wickramasinghe, Munidasa, Hargreaves, Doug, De Pellegrin, Dennis   +2 more
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Dual-heterostructure-enabled mechanical property enhancement and coordinated deformation mechanisms in laminated Mg composite alloys

Materials Research Letters
A laminated Mg-Zn/Mg–Ca composite sheet with dual heterostructures have been fabricated via accumulative roll bonding and annealing. This architecture introduces heterogeneities in both grain sizes and textures.
Ming Yang, Hai-Long Jia, Run Jiang, Xiao-Wei Li, Pin-Kui Ma, Min Zha, Hui-Yuan Wang   +6 more
doaj   +1 more source

Numerical Investigation on the Strain Evolution of Ti-6Al-4V Alloy during Multi-directional Forging at Elevated Temperatures

High Temperature Materials and Processes, 2018
Multi-directional forging (MDF) is one of the most promising severe plastic deformation (SPD) methods used in fabricating large-scale bulk metal materials with ultra-fine grains (UFG). A finite element model for MDF is developed to investigate the strain
Yan Chenkan, Shen Jun, Lin Peng
doaj   +1 more source

Corrosion Behavior of Al-2wt%Cu Alloy Processed By Accumulative Roll Bonding (ARB) Process [PDF]

Journal of Ultrafine Grained and Nanostructured Materials, 2016
Accumulative roll bonding (ARB) imposes severe plastic strain on materials without changing the specimen dimensions. ARB process is mostly appropriate for practical applications because it can be performed readily by the conventional rolling process.
Mohammad Abdolahi Sereshki, Bahram Azad, Ehsan Borhani   +2 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Wetting deformation prediction of compacted lateritic clay subjected to dynamic loading

Journal of Rock Mechanics and Geotechnical Engineering
Rainfall infiltration and groundwater level fluctuation cause the subgrade filler to be wetted, rendering the subgrade prone to accelerated permanent deformation under long-term traffic loading.
Xuanjia Huang, Weizheng Liu, Zhaofeng Chen, Weihao Wang   +3 more
doaj   +1 more source