Results 61 to 70 of about 112,378 (319)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Influence of Transformation Pseudoelasticity and Accumulated Plastic Strain on Low Cycle Fatigue Characteristics of Fe-30Mn-4Si-2Al Alloy

open access: yes, 2018
Synopsis Fe-30Mn-4Si-2Al alloy (mass%) was reported to show excellent low cycle fatigue properties. We investigated fatigue characteristics of the Fe-30Mn-4Si-2Al alloy as a function of accumulative plastic strains, comparing with the low cycle fatigue ...
N. Nagashima, T. Sawaguchi
semanticscholar   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

Finite element modeling of tube deformation during cold pilgering

open access: yesMATEC Web of Conferences, 2016
A three-dimensional finite element model of cold pilgering of stainless steel tubes is developed in this paper. The objective is to use the model to increase the understanding of forces and deformations in the process.
Azizoğlu Yağız   +3 more
doaj   +1 more source

On the Lightweight Potential of Laser Additive Manufactured NiTi Triply Periodic Minimal Sheet Lattices

open access: yesAdvanced Engineering Materials, EarlyView.
This study explores the lightweight potential of laser additive‐manufactured NiTi triply periodic minimal surface sheet lattices. It systematically investigates the effects of relative density and unit cell size on surface quality, deformation recovery, compression behavior, and energy absorption.
Haoming Mo   +3 more
wiley   +1 more source

Ti/Al Multi-Layered Sheets: Differential Speed Rolling (Part B)

open access: yesMetals, 2016
Differential speed rolling has been applied to multi-layered Ti/Al composite sheets, obtained from accumulative roll bonding with intermediate heat treatments being applied.
Jan Romberg   +10 more
doaj   +1 more source

A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions

open access: yesAdvanced Engineering Materials, EarlyView.
This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice   +2 more
wiley   +1 more source

Numerical and experimental investigation of the deformation behavior during the accumulative back extrusion of an AZ91 magnesium alloy

open access: yes, 2018
In the present study, the finite element method (FEM) and an experimental investigation were performed during the accumulative back extrusion (ABE) processing of an AZ91 magnesium alloy in order to investigate the effects of the deformation ratio ...
Faraji, G   +4 more
core   +1 more source

Study on microstructure evolution and fracture behavior of Al/Al/Cu multilayer composites

open access: yesJournal of Materials Research and Technology, 2023
The microstructure evolution, mechanical properties, and the fracture mode of Al/Al/Cu multilayer structural composites produced by accumulative roll bonding (ARB) were investigated by optical microscopy (OM), scanning electron microscopy (SEM), energy ...
Zhiqiang Lei   +7 more
doaj   +1 more source

Microstructural Evolution and Vacancy Defect Formation in Mn–Mo–Ni RPV Steel Under Low Cycle Fatigue: Insights From EBSD and PALS

open access: yesAdvanced Engineering Materials, EarlyView.
Low‐cycle fatigue damage in Mn–Mo–Ni reactor pressure vessel steel is examined using a combined electron backscatter diffraction and positron annihilation lifetime spectroscopy approach. The study correlates texture evolution, dislocation substructure development, and vacancy‐type defect formation across uniform, necked, and fracture regions, providing
Apu Sarkar   +2 more
wiley   +1 more source

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