Results 51 to 60 of about 6,133,448 (253)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Combining Sound and Deep Neural Networks for the Measurement of Jump Height in Sports Science
SensorsJump height tests are employed to measure lower-limb muscle power of athletic and non-athletic populations. The most popular instruments for this purpose are jump mats and, in recent years, smartphone apps, which compute jump height through the manual ...
Lucas Banchero +3 more
doaj +1 more source
Arquivos de Neuro-Psiquiatria, 2009 OBJECTIVE: Image guided stereotactic biopsy (SB) provides cerebral tissue samples for histological analysis from minimal lesions or those that are located in deep regions, being crucial in the elaboration of therapeutic strategies, as well as the ...
Eduardo Urbano da Silva +5 more
doaj +1 more source
Lockeans Maximize Expected Accuracy [PDF]
, 2019 The Lockean Thesis says that you must believe p iff you’re sufficiently confident of it. On some versions, the 'must' asserts a metaphysical connection; on others, it asserts a normative one.
Dorst, Kevin
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
A Study On Developing Fluency And Accuracy Skills In Teaching Turkish As A Second Language
Sakarya University Journal of Education, 2022 The present study aims to determine the development of fluency and accuracy skills, which are among the components of speaking, by language instructors in the process of teaching Turkish as a second language.
Merve Ercan, Bilal Ferhat Karadağ
doaj +1 more source
Accuracy and Credal Imprecision [PDF]
, 2019 Many have claimed that epistemic rationality sometimes requires us to have imprecise credal states (i.e. credal states representable only by sets of credence functions) rather than precise ones (i.e.
Berger, Dominik, Das, Nilanjan
core +1 more source
Decoherence of Quantum-Enhanced Timing Accuracy [PDF]
, 2007 Quantum enhancement of optical pulse timing accuracy is investigated in the Heisenberg picture. Effects of optical loss, group-velocity dispersion, and Kerr nonlinearity on the position and momentum of an optical pulse are studied via Heisenberg ...
G. P. Agrawal +6 more
core +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source