Results 71 to 80 of about 2,704,008 (268)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The Paradox of The Internet in Journalism in Nigeria: Between Flexibility and Accuracy Challenges

Baileo
This study critically examines the role of the internet in the development of journalism in Nigeria, highlighting its benefits, drawbacks, and broader implications for the field.
Kingsley Chukwemeka Izuogu, Onyekwere Okpara, Dennis Ugochukwu Omeonu   +2 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Evaluation of Internal and Marginal Accuracy (Trueness and Precision) of Laminates Using DLP Printing and Milling Methods

Biomimetics
This study evaluated the internal and marginal accuracy (trueness and precision) of zirconia laminate veneers fabricated using the DLP printing and milling method, employing 3D analysis software program.
Mijun Noh, Habin Lee, Wansun Lee, Jaehong Kim, Jihwan Kim   +4 more
doaj   +1 more source

On the Accuracy of Genomic Selection

PLOS ONE, 2016
Genomic selection is focused on prediction of breeding values of selection candidates by means of high density of markers. It relies on the assumption that all quantitative trait loci (QTLs) tend to be in strong linkage disequilibrium (LD) with at least one marker.
Rabier, Charles-Elie, Barre, Philippe, Asp, Torben, Charmet, Gilles, Mangin, Brigitte   +4 more
openaire   +7 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Accuracy of smartwatches in predicting distance running performance

Frontiers in Sports and Active Living
ObjectiveThis study examined the accuracy of smartwatches in predicting running performance.MethodsA total of 154 amateur runners (123 males and 31 females) were recruited. After wearing the HUAWEI WATCH GT Runner for a minimum of six weeks, the runners'
Jiansong Dai, Gangrui Chen, Zhonghe Gu, Yuxuan Qi, Kai Xu   +4 more
doaj   +1 more source

Monitoring Livestock Health by Modeling Rumination Behavior According to Accelerometer-Based Information [PDF]

Journal of Agricultural Machinery
IntroductionThe livestock sector excels in the production of dairy and meat products. These products, serving as vital sources of animal protein, hold a significant position in household diets.
E. Vahedi Tekmehdash, H. Navid, H. Ghasemzadeh, H. Karimi, M. Javani Holan   +4 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

On Expected Accuracy

CoRR, 2019
We empirically investigate the (negative) expected accuracy as an alternative loss function to cross entropy (negative log likelihood) for classification tasks. Coupled with softmax activation, it has small derivatives over most of its domain, and is therefore hard to optimize. A modified, leaky version is evaluated on a variety of classification tasks,
openaire   +2 more sources