Results 71 to 80 of about 6,133,448 (253)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Improving the classification of a nanocomposite using nanoparticles based on a meta-analysis study, recurrent neural network and recurrent neural network Monte-Carlo algorithms

Nanocomposites
This paper may be the first meta-analysis that presents a comprehensive synthesis of scientific works spanning the last five years, focusing on methodologies and results related to the analysis of nanocomposite using nanoparticles.
Rania Loukil, Wejden Gazehi, Mongi Besbes   +2 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Tele Dentistry: An Advancement Tool in Dentistry [PDF]

Dental Journal of Advance Studies
Background: The study documented below was conducted to highlight the accuracy of diagnosing caries in human teeth by examination of the intraoral photographs taken through the smartphone vs standard clinical examination through the dental operating ...
Navjot S Mann, Stuti Aggarwal, Ashu Jhamb, Divya Batra, Nikita Saraf   +4 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Preserving Accuracy in GenBank [PDF]

Science, 2008
GenBank, the public repository for nucleotide and protein sequences, is a critical resource for molecular biology, evolutionary biology, and ecology. While some attention has been drawn to sequence errors ([1][1]), common annotation errors also reduce the value of this database.
Bruns, Thomas D., Blackwell, Meredith, Edwards, Ivan, Taylor, Andy F. S., Horton, Thomas, Zhang, Ning, Kõljalg, Urmas, May, Georgiana, Kuyper, Thomas W., Bever, James D., Gilbert, Gregory, Taylor, John W., DeSantis, Todd Z., Pringle, Anne, Borneman, James, Thorn, Greg, Berbee, Mary, Mueller, Gregory M., Andersen, Gary L., Vellinga, Else C., Branco, Sara, Anderson, Ian, Dickie, Ian A., Avis, Peter, Timonen, Sari, Kjøller, Rasmus, Lodge, D. J., Bateman, Richard M., Purvis, Andy, Crous, Pedro W., Hawkes, Christine, Barraclough, Tim, Burt, Austin, Nilsson, R. H., Larsson, Karl-Henrik, Alexander, Ian, Moncalvo, Jean-Marc, Berube, Jean, Spatafora, Joseph, Thorsten Lumbsch, H., Blair, Jaime E., Suh, Sung-Oui, Pfister, Donald H., Binder, Manfred, Boehm, Eric W., Kohn, Linda, Mata, Juan L., Dyer, Paul, Sung, Gi-Ho, Dentinger, Bryn, Simmons, Emory G., Baird, Richard E., Volk, Thomas J., Perry, Brian A., Kerrigan, Richard W., Campbell, Jinx, Rajesh, Jeewon, Reynolds, Don R., Geiser, David, Humber, Richard A., Hausmann, Natasha, Szaro, Tim, Stajich, Jason, Gathman, Allen, Peay, Kabir G., Henkel, Terry, Robinson, Clare H., Pukkila, Patricia J., Nguyen, Nhu H., Villalta, Christopher, Kennedy, Peter, Bergemann, Sarah, Catherine Aime, M., Kauff, Frank, Porras-Alfaro, Andrea, Gueidan, Cecile, Beck, Andreas, Andersen, Birgitte, Marek, Stephen, Crouch, Jo A., Kerrigan, Julia, Beagle Ristaino, Jean, Hodge, Kathie T., Kuldau, Gretchen, Samuels, Gary J., Raja, Huzefa A., Voglmayr, Hermann, Gardes, Monique, Janos, David P., Rogers, Jack D., Cannon, Paul, Woolfolk, Sandra W., Kistler, H. C., Castellano, Michael A., Maldonado-Ramírez, Sandra L., Kirk, Paul M., Farrar, James J., Osmundson, Todd, Currah, Randolph S., Vujanovic, Vladimir, Chen, Weidong, Korf, Richard P., Atallah, Zahi K., Harrison, Ken J., Guarro, Josep, Bates, Scott T., Enrico Bonello, Pierluigi, Bridge, Paul, Schell, Wiley, Rossi, Walter, Stenlid, Jan, Frisvad, Jens C., Miller, R. M., Baker, Scott E., Hallen, Heather E., Janso, Jeffrey E., Wilson, Andrew W., Conway, Kenneth E., Egerton-Warburton, Louise, Wang, Zheng, Eastburn, Darin, Ho, Wellcome W. Hong, Kroken, Scott, Stadler, Marc, Turgeon, Gillian, Lichtwardt, Robert W., Stewart, Elwin L., Wedin, Mats, Li, De-Wei, Uchida, Janice Y., Jumpponen, Ari, Deckert, Ron J., Beker, Henry J., Rogers, Scott O., Xu, Jianping, Johnston, Peter, Shoemaker, R. A., Liu, Miao, Marques, G., Summerell, Brett, Sokolski, Serge, Thrane, Ulf, Widden, Paul, Bruhn, Johann N., Bianchinotti, Virginia, Tuthill, Dorothy, Baroni, Timothy J., Barron, George, Hosaka, Kentaro, Jewell, Kelsea, Piepenbring, Meike, Sullivan, Raymond, Griffith, Gareth W., Bradley, S. G., Aoki, Takayuki, Yoder, Wendy T., Ju, Yu-Ming, Berch, Shannon M., Trappe, Matt, Duan, Weijun, Bonito, Gregory, Taber, Ruth A., Coelho, Gilberto, Bills, Gerald, Ganley, Austen, Agerer, Reinhard, Nagy, László, Roy, Barbara A., Læssøe, Thomas, Hallenberg, Nils, Tichy, Hans-Volker, Stalpers, Joost, Langer, Ewald, Scholler, Markus, Krueger, Dirk, Pacioni, Giovanni, Pöder, Reinhold, Pennanen, Taina, Capelari, Marina, Nakasone, Karen, Tewari, J. P., Miller, Andrew N., Decock, Cony, Huhndorf, Sabine, Wach, Mark, Vishniac, Helen S., Yohalem, David S., Smith, Matthew E., Glenn, Anthony E., Spiering, Martin, Lindner, Daniel L., Schoch, Conrad, Redhead, Scott A., Ivors, Kelly, Jeffers, Steven N., Geml, József, Okafor, Florence, Spiegel, Frederick W., Dewsbury, Damon, Carroll, Juliet, Pashley, Catherine, Taylor, D. L., Liles, Mark R., Cruse-Sanders, Jennifer, Hynson, Nicole   +204 more
openaire   +3 more sources

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source