Results 81 to 90 of about 2,704,008 (268)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Comparative Analysis of Gradient Descent Learning Algorithms in Artificial Neural Networks for Forecasting Indonesian Rice Prices

Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi)
Artificial Neural Networks (ANN) are a field of computer science that mimics the way the human brain processes data. ANNs can be used to classify, estimate, predict, or simulate new data from similar sources. The commonly used algorithm for prediction in
Rica Ramadana, Agus Perdana Windarto, Dedi Suhendro   +2 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

The Performance qualification of automatic volumetric pipettes used in university hospitals in the DRC: Case of Kinshasa, Bukavu, and Kisangani

Orapuh Journal
Introduction Automatic micropipettes are widely used in clinical biology for quantitative analyses in medical diagnostics. However, in many hospitals in developing countries, this equipment is often not verified for accuracy in collecting biological ...
Joenna Bapite Musongiela, Jocelyn Mankulu Kakumba, Emile Tweni Baruti, Timothé Mavanga Mabaya, Jacquie Bolavie Bolande, Sara Munguakonkwa Byamungu , Jérémie Mbinze Kindenge   +6 more
doaj   +1 more source

On the Accuracy of Language Trees

PLoS ONE, 2011
Historical linguistics aims at inferring the most likely language phylogenetic tree starting from information concerning the evolutionary relatedness of languages. The available information are typically lists of homologous (lexical, phonological, syntactic) features or characters for many different languages.
Simone Pompei, TRIA, FRANCESCA, LORETO, Vittorio   +2 more
openaire   +6 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Investigation of the accuracy of BeiDou, QZSS and QZSS/BeiDou satellites configuration for short, medium and long baselines in the Asia-Pacific regions

Reports on Geodesy and Geoinformatics
The field of satellite navigation has seen significant advancements due to the fast development of multi-constellation Global Navigation Satellite Systems (GNSS).
Pirti Atinç
doaj   +1 more source

INNOVATIVE APPROACHES TO ENHANCING USER SATISFACTION IN HIGHER EDUCATION INFORMATION SYSTEMS

Science Journal of University of Zakho
In order to assess how effective information systems are, end-user computing satisfaction (EUCS) is essential. This study evaluates EUCS among 354 employees of the Iraqi Kurdistan Region's (KRI) Ministry of Higher Education and Scientific Research ...
Aso K. Ameen , Ismail Y. Maolood , Dana A. Abdullah   +2 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source