Results 71 to 80 of about 8,276,674 (332)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A high accuracy computed water line list

, 2006
A computed list of H$_{2}$$^{16}$O infra-red transition frequencies and intensities is presented. The list, BT2, was produced using a discrete variable representation two-step approach for solving the rotation-vibration nuclear motions.
Alexander, Allard, Allard, Banerjee, Barber, Barlow, Bačić, Bernath, Bernath, Bunker, Camy-Peyret, Carr, Carter, Cernicharo, Cheung, Coheur, Dello Russo, Dello Russo, Dello Russo, Dupré, G. J. Harris, Gensheimer, González-Alfonso, Hauschildt, Hinkle, J. Tennyson, Jennings, Jones, Jørgensen, Ludvig, Lynas-Gray, Miani, Miller, Mumma, Mussa, Partridge, Polyansky, Polyansky, R. J. Barber, R. N. Tolchenov, Ryde, Schwenke, Schwenke, Shiba, Shirin, Smith, Smith, Tennyson, Tennyson, Tennyson, Tennyson, Tolchenov, Tsuji, Tsuji, Vidler, Viti, Viti, Volk, Wallace, Wallace, Zobov, Zobov, Zobov   +62 more
core   +3 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Jet Physics at Two-Loop Accuracy

, 2002
Current phenomenological studies of jet observables at colliders are clearly limited by the theoretical uncertainties inherent in the next-to-leading order QCD description. We discuss the recent progress made towards the calculation of QCD corrections to
Anastasiou, Anastasiou, Anastasiou, Anastasiou, Anastasiou, Anastasiou, Anastasiou, Anastasiou, Berends, Bern, Bern, Bern, Bern, Bern, Bern, Bern, Binoth, Campbell, Campbell, Campbell, Catani, Catani, Catani, Catani, Catani, Chetyrkin, Dixon, Dixon, Ellis, Fabricius, Garland, Garland, Gehrmann, Gehrmann, Gehrmann, Gehrmann, Gehrmann, Gehrmann, Gehrmann, Gehrmann-De Ridder, Gehrmann-De Ridder, Giele, Glover, Glover, Hooft, Kosower, Kosower, Kölbig, Kölbig, Laporta, Lewin, Moch, Nagy, Nagy, Nagy, Nielsen, Remiddi, Smirnov, Smirnov, Smirnov, Smirnov, Smirnov, T. Gehrmann, Tausk, Tkachov, Weinzierl, Weinzierl   +66 more
core   +2 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Testing surface area with arbitrary accuracy

, 2014
Recently, Kothari et al.\ gave an algorithm for testing the surface area of an arbitrary set $A \subset [0, 1]^n$. Specifically, they gave a randomized algorithm such that if $A$'s surface area is less than $S$ then the algorithm will accept with high ...
Bakry D., Federer H., Kothari P., Santaló L. A.   +3 more
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Accuracy of vertical velocity determination [PDF]

, 1983
Typical wind spectra taken at Poker Flat, Alaska, using the vertically oriented antenna show velocities of 10's of cm to meters per second and spectral widths winds of 0.5 to 1 m/s.
Riddle, A. C.
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source