Results 91 to 100 of about 77,670 (298)

The ACE2/Apelin Signaling, MicroRNAs, and Hypertension [PDF]

International Journal of Hypertension, 2015
The renin-angiotensin aldosterone system (RAAS) plays a pivotal role in the development of hypertension. Angiotensin converting enzyme 2 (ACE2), which primarily metabolises angiotensin (Ang) II to generate the beneficial heptapeptide Ang-(1-7), serves as a negative regulator of the RAAS.
Hui Min Yu, Jiu Chang Zhong, Qing Chang, Lai Jiang Chen, Ran Xu   +4 more
openaire   +3 more sources

Progress in Surface Plasmon and Other Resonance Biosensors for Biomedical Applications

Advanced Materials Technologies, EarlyView.
This is the shortened version: Recent advancements in surface plasmon resonance and other optical resonance biosensors for biomedical applications are presented. Advanced sensing strategies are examined for the detection of diverse analytes, integration of nanomaterials and machine learning, and emerging nonplasmonic modes like guided mode resonance ...
Faten Bashar Kamal Eddin, Houxin Fan, Zhenchao Liu, Paolo Donati, Youssef Amin, Yap Wing Fen, Junbo Liang, Pier Paolo Pompa, Sailing He   +8 more
wiley   +1 more source

Androgen receptor polyQ alleles and COVID‐19 severity in men: A replication study

Andrology, Volume 11, Issue 1, Page 24-31, January 2023., 2023
Abstract Background Ample evidence indicates a sex‐related difference in severity of COVID‐19, with less favorable outcomes observed in men. Genetic factors have been proposed as candidates to explain this difference. The polyglutamine (polyQ) polymorphism in the androgen receptor gene has been recently described as a genetic biomarker of COVID‐19 ...
Rosario López‐Rodríguez, Javier Ruiz‐Hornillos, Marta Cortón, Berta Almoguera, Pablo Minguez, María Elena Pérez‐Tomás, María Barreda‐Sánchez, Esther Mancebo, Lorena Ondo, Andrea Martínez‐Ramas, Lidia Fernández‐Caballero, Juan Carlos Taracido‐Fernández, Antonio Herrero‐González, Ignacio Mahillo, The STOP_Coronavirus Study Group, Estela Paz‐Artal, Encarna Guillén‐Navarro, Carmen Ayuso   +17 more
wiley   +1 more source

Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury

Advanced Science, EarlyView.
Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi, Yanxia Wang, Huan Chen, Kaitian Wu, Pei Zhou, Yue Dou, Bingqi Xiong, Wei Zhou   +7 more
wiley   +1 more source

Mathematical model of SARS-Cov-2 propagation versus ACE2 fits COVID-19 lethality across age and sex and predicts that of SARS, supporting possible therapy [PDF]

arXiv, 2020
The fatality rate of Covid-19 escalates with age and is larger in men than women. I show that these variations correlate strongly with the level of the viral receptor protein ACE2 in rat lungs, which is consistent with the still limited and apparently contradictory data on human ACE2.
arxiv  

Angiotensin Converting Enzyme (ACE) and ACE2 Bind Integrins and ACE2 Regulates Integrin Signalling

PLoS ONE, 2012
The angiotensin converting enzymes (ACEs) are the key catalytic components of the renin-angiotensin system, mediating precise regulation of blood pressure by counterbalancing the effects of each other. Inhibition of ACE has been shown to improve pathology in cardiovascular disease, whilst ACE2 is cardioprotective in the failing heart.
Clarke, N.E., Fisher, M.J., Porter, K.E., Lambert, D.W., Turner, A.J.   +4 more
openaire   +5 more sources

Pan‐Variant SARS‐CoV‐2 Vaccines Induce Protective Immunity by Targeting Conserved Epitopes

Advanced Science, EarlyView.
An integrative approach identifies conserved B‐cell and T‐cell epitopes within SARS‐CoV‐2 proteins, redirecting immune responses from variable to conserved regions. These epitopes elicit robust humoral and cellular immunity, neutralizing diverse viral variants. Promiscuous T‐cell epitopes demonstrate cross‐species efficacy, highlighting their potential
Masaud Shah, Sung Ung Moon, Ji‐Yon Shin, Ji‐Hye Choi, Doyoon Kim, Hyun Goo Woo   +5 more
wiley   +1 more source

Role of ACE 2 and Vitamin D: The Two Players in Global Fight against COVID-19 Pandemic

Annals of the National Academy of Medical Sciences (India), 2021
The global pandemic of coronavirus disease 2019 (COVID-19) has spread across the borders, gaining attention from both health care professional and researchers to understand the mode of entry and actions induced by severe acute respiratory syndrome ...
Tapan Behl, Sadia Shah, Ishnoor Kaur, Sushma Yadav, Raj Kanwar, Sandeep Seth, Naveet Wig, K. K. Sharma, Harlokesh Narayan Yadav   +8 more
doaj   +1 more source

A Versatile High‐Throughput Single‐Cell Screening Platform for Profiling Antigen‐Specific Long‐Lived B Cells in Blood and Bone Marrow

Advanced Science, EarlyView.
The MoSMAR‐chip platform provides a high‐throughput and cost‐effective tool for identifying and characterizing antigen‐specific antibody‐secreting cells (ASCs) and memory B cells (MBCs) at the single‐cell level. The ASCs from coronavirus disease 2019 (COVID‐19) vaccine‐immunized mice were successfully analyzed, revealing diverse neutralizing antibodies
Tian Zhao, Yuqing Lei, Chang Liu, Dong Zhang, Kaiyi Li, Sisi Shan, Chenyu Li, Zimeng Wei, Yuhan Yang, Ting Zhang, Kai Sun, Haoran Sun, Linqi Zhang, Peng Liu   +13 more
wiley   +1 more source

The Role of the Ocular Tissue in SARS-CoV-2 Transmission

Clinical Ophthalmology, 2020
Michael Peng,1 Jiannong Dai,1 Chenna Kesavulu Sugali,1 Naga Pradeep Rayana,1 Weiming Mao1,2 1Department of Ophthalmology, Eugene & Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, USA; 2Department of Biochemistry ...
Peng M, Dai J, Sugali CK, Rayana NP, Mao W   +4 more
doaj