Results 91 to 100 of about 149,286 (348)

EZH2-mediated H3K27me3 inhibits ACE2 expression

Biochemical and Biophysical Research Communications, 2020
The outbreak of corona virus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is spreading globally and quickly, leading to emerging health issues. SARS-CoV-2 enters into and infects host cells through its spike glycoprotein recognizing the cell receptor Angiotensin-converting enzyme II (ACE2).
Li, Yuanyuan, Li, Honggang, Zhou, Liquan
openaire   +2 more sources

Angiotensin Converting Enzyme (ACE) and ACE2 Bind Integrins and ACE2 Regulates Integrin Signalling

PLoS ONE, 2012
The angiotensin converting enzymes (ACEs) are the key catalytic components of the renin-angiotensin system, mediating precise regulation of blood pressure by counterbalancing the effects of each other. Inhibition of ACE has been shown to improve pathology in cardiovascular disease, whilst ACE2 is cardioprotective in the failing heart.
Clarke, N.E., Fisher, M.J., Porter, K.E., Lambert, D.W., Turner, A.J.   +4 more
openaire   +5 more sources

ACE2 and Diabetes: ACE of ACEs? [PDF]

Diabetes, 2010
The mechanisms involved in the development of diabetes and its complications are complex, with a long list of potential derangements on different pathways (1,2). In this commentary, we discuss angiotensin converting enzyme 2 (ACE2) as a potential participant in the development of both islet β-cell insufficiency early on and in the development of ...
Batlle, Daniel, Jose Soler, Maria, Ye, Minghao   +2 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Glyceraldehyde-3-Phosphate Dehydrogenase Binds with Spike Protein and Inhibits the Entry of SARS-CoV-2 into Host Cells

Journal of Innate Immunity
Introduction: Coronavirus disease 2019 caused by coronavirus-2 (SARS-CoV-2) has emerged as an aggressive viral pandemic. Health care providers confront a challenging task for rapid development of effective strategies to combat this and its long-term ...
Rahul Dilawari, Gaurav Kumar Chaubey, Radheshyam Modanwal, Asmita Dhiman, Sharmila Talukdar, Ajay Kumar, Chaaya Iyengar Raje, Manoj Raje   +7 more
doaj   +1 more source

Aging- and gender-related modulation of RAAS: potential implications in COVID-19 disease

Vascular Biology, 2021
Coronavirus disease 2019 (COVID-19) is a new infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is frequently characterized by a marked inflammatory response with severe pneumonia and respiratory failure ...
Laura Monteonofrio, Maria Cristina Florio, Majd AlGhatrif, Edward G Lakatta, Maurizio C Capogrossi   +4 more
doaj   +1 more source

Impaired nutrient signaling and body weight control in a Na⁺ neutral amino acid cotransporter (Slc6a19)-deficient mouse [PDF]

, 2015
Amino acid uptake in the intestine and kidney is mediated by a variety of amino acid transporters. To understand the role of epithelial neutral amino acid uptake in whole body homeostasis, we analyzed mice lacking the apical broad-spectrum neutral (0 ...
Bailey, Charles G., Bröer, Angelika, Bröer, Stefan, Holst, Jeff, Juelich, Torsten, Rasko, John E J, Solomon, Peter S, Tietze, Nadine, Vanslambrouck, Jessica M   +8 more
core   +1 more source

Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations

Cell Discovery, 2020
Dear Editor, The ACE2 gene encodes the angiotensin-converting enzyme-2, which has been proved to be the receptor for both the SARS-coronavirus (SARS-CoV) and the human respiratory coronavirus NL63.
Yanan Cao, Lin Li, Zhimin Feng, Shengqing Wan, Peide Huang, Xiaohui Sun, Fang Wen, Xuanlin Huang, G. Ning, Weiqing Wang   +9 more
semanticscholar   +1 more source

ACE2 and gut amino acid transport

Clinical Science, 2020
Abstract ACE2 is a type I membrane protein with extracellular carboxypeptidase activity displaying a broad tissue distribution with highest expression levels at the brush border membrane (BBM) of small intestine enterocytes and a lower expression in stomach and colon.
Camargo, Simone M.R., Vuille-dit-Bille, Raphael N., Meier, Chantal F., Verrey, François   +3 more
openaire   +2 more sources

Effect of age on human ACE2 and ACE2-expressing alveolar type II cells levels

Pediatric Research, 2022
Angiotensin-converting enzyme 2 (ACE2) is the receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19. Viral entry requires ACE2 and transmembrane protease serine 2 (TMPRSS2). Transcriptomic studies showed that children display lower ACE2 than adults, though gene expression levels do not always correlate with ...
Silva, Mauro Gastón, Falcoff, Nora L., Corradi, Gerardo Raul, Di Camillo, Norma Alicia, Seguel, Rolando F., Tabaj, Gabriela C., Guman, Gabriela R., de Matteo, Elena Noemí, Nuñez, Myriam, Gironacci, Mariela Mercedes   +9 more
openaire   +3 more sources