Results 71 to 80 of about 132,338 (329)

Differential renal effects of candesartan at high-and ultra-high doses in diabetic mice: potential role of  ACE2/AT2R/Mas [PDF]

, 2016
High doses of Ang II receptor (AT1R) blockers (ARBs) are renoprotective in diabetes. Underlying mechanisms remain unclear. We evaluated whether high/ultra-high doses of candesartan (ARB) up-regulate angiotensin-converting enzyme 2 (ACE2)/Ang II type 2 ...
Antunes, Tayze, Briones, Ana M., Burns, Kevin, Callera, Glaucia, Correa, Jose, Gutsol, Alexey, He, Ying, Montezano, Augusto C., Moorman, Danielle, Nguyen Dinh Cat, Aurelie, Touyz, Rhian M.   +10 more
core   +1 more source

ACE2 and gut amino acid transport

Clinical Science, 2020
Abstract ACE2 is a type I membrane protein with extracellular carboxypeptidase activity displaying a broad tissue distribution with highest expression levels at the brush border membrane (BBM) of small intestine enterocytes and a lower expression in stomach and colon.
Camargo, Simone M.R., Vuille-dit-Bille, Raphael N., Meier, Chantal F., Verrey, François   +3 more
openaire   +2 more sources

Effect of age on human ACE2 and ACE2-expressing alveolar type II cells levels

Pediatric Research, 2022
Angiotensin-converting enzyme 2 (ACE2) is the receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19. Viral entry requires ACE2 and transmembrane protease serine 2 (TMPRSS2). Transcriptomic studies showed that children display lower ACE2 than adults, though gene expression levels do not always correlate with ...
Silva, Mauro Gastón, Falcoff, Nora L., Corradi, Gerardo Raul, Di Camillo, Norma Alicia, Seguel, Rolando F., Tabaj, Gabriela C., Guman, Gabriela R., de Matteo, Elena Noemí, Nuñez, Myriam, Gironacci, Mariela Mercedes   +9 more
openaire   +3 more sources

Biomimetic Copper Nanoparticles Coated with ACE2‐Overexpressing Membranes for Selective SARS‐CoV‐2 Neutralization and Disinfection

Advanced Healthcare Materials, EarlyView.
By fusing ACE2‐overexpressing membrane‐integrated liposome (MIL) with copper nanoparticles, the biomimetic Cu@MIL nanostructures were created that directly hijack the SARS‐CoV‐2 entry pathway. These particles combine potent virus‐targeting precision with intrinsic antiviral activity, achieving rapid neutralization and disinfection.
Pooja Aich, Wei‐Pang Chung, Wen‐Jyun Wang, Hidenobu Takahashi, Ming‐Shun Hsieh, Ying‐Chen Lin, Oh Seok Kwon, Wei‐Peng Li, Wei‐Lun Huang   +8 more
wiley   +1 more source

Epigenetic mechanisms regulating COVID-19 infection

Epigenetics, 2021
Coronavirus disease 2019 (COVID-2019) outbreak originating in December 2019 in Wuhan, China has emerged as a global threat to human health. The highly contagious SARS-CoV-2 infection and transmission presents a diversity of human host and increased ...
Sarantis Chlamydas, Athanasios G. Papavassiliou, Christina Piperi   +2 more
doaj   +1 more source

Evolutionary Analysis of Mammalian ACE2 and the Key Residues Involved in Binding to the Spike Protein Revealed Potential SARS-CoV-2 Hosts

Journal of Medical Microbiology and Infectious Diseases, 2022
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2) spilled over to humans via wild mammals, entering the host cell using angiotensin-converting enzyme 2 (ACE2) as receptor through Spike (S) protein binding.
Luciano Rodrigo Lopes1, Natália Carvalho de Lucca Pina1, Antonio Carlos da Silva Junior1, Paulo- Bandiera Paiva1   +3 more
doaj   +1 more source

P-030 ACE2 receptor and its isoform short-ACE2 are expressed on human spermatozoa

Human Reproduction, 2022
Abstract Study question Do human spermatozoa express angiotensin-converting enzyme 2 (ACE2) receptor? What would be its localization? Summary answer Human spermatozoa express uniformly ACE2 on the sperm head and the flagellum ...
Ramal Sanchez, M, Castellini, C, Cimini, C, Taraschi, A, Valbonetti, L, Barbonetti, A, Bernabo, Nicola, Barboni, B   +7 more
openaire   +2 more sources

Viral Infection‐Inspired Autonomous Detection of Fusion‐Competent Viruses for Screening and Environmental Surveillance

Advanced Materials, EarlyView.
Inspired by viral entry mechanisms, the FUSION assay enables autonomous detection of respiratory viruses via membrane fusion–triggered CRISPR‐Cas13a activation. VEACON selectively fuses with fusion‐competent viruses, triggering fluorescence within confined vesicles.
Jae Chul Park, Yidam Song, Hyun‐Woo Choi, Jaeuk Sung, Harin Jin, WonSeok Gwak, Kirim Yoo, Soohwang Lee, Jongeon Park, Jeongmin Kim, Hye‐Jun Jo, Jahyun Koo, Youngdo Jeong, Kwan Hyi Lee, Seung‐Jung Kee, Hojun Kim   +15 more
wiley   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases

Journal of Inflammation Research, 2021
Avaniyapuram Kannan Murugan,1 Ali S Alzahrani1,2 1Division of Molecular Endocrinology, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, 11211, Saudi Arabia; 2Department of Medicine, King Faisal Specialist ...
Murugan AK, Alzahrani AS
doaj